日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of Structurally Novel KRAS(G12C) Inhibitors through Covalent DNA-Encoded Library Screening

通过共价DNA编码文库筛选鉴定结构新颖的KRAS(G12C)抑制剂

Huang, David; Manoni, Francesco; Sun, Zhen; Liu, Rongfeng; Allen, Jennifer R; Banerjee, Abhisek; Cee, Victor J; Eshon, Josephine; Frohn, Michael J; Kaller, Matthew R; Lee, Heejun; Li, Cui; Li, Xun; Lopez, Patricia; Ma, Vu; Medina, Jose M; Mohr, Christopher; Mukhina, Olga A; Pickrell, Alexander J; Stellwagen, John; Wu, Wenting; Zhang, Wenhan; Zhu, Kai; Dahal, Upendra P; Hu, Liaoyuan A; Leavitt, Monica; Li, Wencui; Li, Yu; Ma, Yingli; Rex, Karen; Saiki, Anne Y; Wang, Paul; Sun, Yaping; Dai, Dongcheng; Tamayo, Nuria A; Lanman, Brian A

From DNA-Encoded Library Screening to AM-9747: An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy.

从 DNA 编码文库筛选到 AM-9747:一种具有强效口服体内疗效的 MTA 协同 PRMT5 抑制剂

Sarvary Ian, Vestergaard Mikkel, Moretti Loris, Andersson Jan, Peiró Cadahía Jorge, Cowland Sanne, Flagstad Thomas, Franch Thomas, Gouliaev Alex, Husemoen Gitte, Jacso Tomas, Kronborg Titi, Kuropatnicka Aleksandra, Nadali Anna, Madsen Mads, Nielsen So Ren, Pii David, Ryborg So Ren, Soede Camillia, Allen Jennifer R, Bourbeau Matthew, Li Kexue, Liu Qingyian, Lo Mei-Chu, Madoux Franck, Mardirossian Narbe, Moriguchi Jodi, Ngo Rachel, Peng Chi-Chi, Pettus Liping, Tamayo Nuria, Wang Paul, Kapoor Rajiv, Belmontes Brian, Caenepeel Sean, Hughes Paul, Liu Siyuan, Slemmons Katherine K, Yang Yajing, Xie Fang, Ghimire-Rijal Sudipa, Mukund Susmith, Glad Sanne

Discovery of Phosphodiesterase 10A (PDE10A) PET Tracer AMG 580 to Support Clinical Studies

发现磷酸二酯酶 10A (PDE10A) PET 示踪剂 AMG 580 以支持临床研究

Hu, Essa; Chen, Ning; Kunz, Roxanne K; Hwang, Dah-Ren; Michelsen, Klaus; Davis, Carl; Ma, Ji; Shi, Jianxia; Lester-Zeiner, Dianna; Hungate, Randall; Treanor, James; Chen, Hang; Allen, Jennifer R