日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Loss of cystathionine-β-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome.

胱硫醚β-合成酶的缺失导致氧化磷酸化水平升高,这是唐氏综合征中阿糖胞苷耐药性髓系白血病的一个弱点。

Thibodeau Jenna, Zhao Jianlei, Edwards Holly, Polin Lisa, Kushner Juiwanna, Dzinic Sijana H, White Kathryn, Hershberger Kian, Su Yongwei, Arroum Tasnim, Pham Lucynda, Pavelich Lauren, Awdish Raina, LaValley Jacob, Boucher Austin C, Chen Wei, Li Jing, Bao Xun, Hüttemann Maik, Back Jessica B, Allen Joshua E, Prabhu Varun V, Crispino John D, Taub Jeffrey W, Ge Yubin

Correction: Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

更正:ONC201治疗H3K27M突变型弥漫性中线胶质瘤的临床疗效是由整合代谢和表观遗传通路紊乱驱动的

Venneti, Sriram; Kawakibi, Abed Rahman; Ji, Sunjong; Waszak, Sebastian M; Sweha, Stefan R; Mota, Mateus; Pun, Matthew; Deogharkar, Akash; Chung, Chan; Tarapore, Rohinton S; Ramage, Samuel; Chi, Andrew; Wen, Patrick Y; Arrillaga-Romany, Isabel; Batchelor, Tracy T; Butowski, Nicholas A; Sumrall, Ashley; Shonka, Nicole; Harrison, Rebecca A; de Groot, John; Mehta, Minesh; Hall, Matthew D; Daghistani, Doured; Cloughesy, Timothy F; Ellingson, Benjamin M; Beccaria, Kevin; Varlet, Pascale; Kim, Michelle M; Umemura, Yoshie; Garton, Hugh; Franson, Andrea; Schwartz, Jonathan; Jain, Rajan; Kachman, Maureen; Baum, Heidi; Burant, Charles F; Mottl, Sophie L; Cartaxo, Rodrigo T; John, Vishal; Messinger, Dana; Qin, Tingting; Peterson, Erik; Sajjakulnukit, Peter; Ravi, Karthik; Waugh, Alyssa; Walling, Dustin; Ding, Yujie; Xia, Ziyun; Schwendeman, Anna; Hawes, Debra; Yang, Fusheng; Judkins, Alexander R; Wahl, Daniel; Lyssiotis, Costas A; Nava, Daniel de la; Alonso, Marta M; Eze, Augustine; Spitzer, Jasper; Schmidt, Susanne V; Duchatel, Ryan J; Dun, Matthew D; Cain, Jason E; Jiang, Li; Stopka, Sylwia A; Baquer, Gerard; Regan, Michael S; Filbin, Mariella G; Agar, Nathalie Y R; Zhao, Lili; Kumar-Sinha, Chandan; Mody, Rajen; Chinnaiyan, Arul; Kurokawa, Ryo; Pratt, Drew; Yadav, Viveka N; Grill, Jacques; Kline, Cassie; Mueller, Sabine; Resnick, Adam; Nazarian, Javad; Allen, Joshua E; Odia, Yazmin; Gardner, Sharon L; Koschmann, Carl

The use of minor response, volumetric assessment, and growth rate kinetics as endpoints in grade 1-3 glioma clinical trials: a RANO perspective

在 1-3 级胶质瘤临床试验中,以轻微反应、体积评估和生长速率动力学作为终点指标:RANO 的视角

van den Bent, Martin J; Cloughesy, Timothy F; Ellingson, Benjamin M; Allen, Joshua E; Blackman, Samuel C; Kieran, Mark W; Tonn, Joerg C; Karschnia, Philipp; Wijnenga, Maarten; Pallud, Johan; Young, Robert J; Huang, Raymond Y; Mellinghoff, Ingo K; de Groot, John; van der Hoorn, Anouk; Youssef, Gilbert; Hervey-Jumper, Shawn L; Vogelbaum, Michael A; Chang, Susan M; Wen, Patrick Y

Prognostic Features of Recurrent Midline and H3 K27M-Mutant Glioma

复发性中线胶质瘤和H3 K27M突变型胶质瘤的预后特征

Bagley, Stephen J; Umemura, Yoshie; Mendez, Joe S; Arrillaga-Romany, Isabel; Bielamowicz, Kevin J; Butowski, Nick; Hutchins, Kelley; Kong, Xiao-Tang; Odia, Yazmin; Sharma, Akanksha; Weintraub, Lauren; Koschmann, Carl; Wen, Patrick Y; Saratsis, Amanda M; Brundage, Tom; Ramage, Samuel C; Tarapore, Rohinton S; Knowles, Truman; Yang, Dewen; Allen, Joshua E; Cloughesy, Timothy

TMET-26. Allosteric ClpP agonist ONC206 alters mitochondrial metabolism and stress response to elicit apoptosis in meningioma

TMET-26。变构ClpP激动剂ONC206通过改变线粒体代谢和应激反应诱导脑膜瘤细胞凋亡。

Mahawar, Usha; Davis, Deanna L; Kannan, Muthukumar; Suemitsu, John; Oltorik, Christopher D; Farooq, Faheem; Fulani, Raheema; Weintraub, Collin; Allegood, Jeremy; Wattenberg, Binks; Lee, Andrew K; Maranto, Cristina; Foster, Scott; Prabhu, Varun V; Allen, Joshua E

ONC206 demonstrates potent anti-tumorigenic activity and is a potential novel therapeutic strategy for high-risk medulloblastoma

ONC206 显示出强大的抗肿瘤活性,是一种潜在的高危髓母细胞瘤新型治疗策略。

Tzaridis, Theophilos; Liu, Jingbo; Chien, Franklin Lee; Malhotra, Anshu; Zhu, Dan; Gershon, Isabella; Zhang, Hongying; Velazquez Vega, Jose E; Schniederjan, Matthew; Sposito, Teresa; Adams, Peter D; Allen, Joshua E; Prabhu, Varun V; Wechsler-Reya, Robert J; MacDonald, Tobey J

ONC201 (Dordaviprone) in Recurrent H3 K27M-Mutant Diffuse Midline Glioma

ONC201(多达韦普隆)用于治疗复发性H3 K27M突变弥漫性中线胶质瘤

Arrillaga-Romany, Isabel; Gardner, Sharon L; Odia, Yazmin; Aguilera, Dolly; Allen, Joshua E; Batchelor, Tracy; Butowski, Nicholas; Chen, Clark; Cloughesy, Timothy; Cluster, Andrew; de Groot, John; Dixit, Karan S; Graber, Jerome J; Haggiagi, Aya M; Harrison, Rebecca A; Kheradpour, Albert; Kilburn, Lindsay B; Kurz, Sylvia C; Lu, Guangrong; MacDonald, Tobey J; Mehta, Minesh; Melemed, Allen S; Nghiemphu, Phioanh Leia; Ramage, Samuel C; Shonka, Nicole; Sumrall, Ashley; Tarapore, Rohinton S; Taylor, Lynne; Umemura, Yoshie; Wen, Patrick Y

Correction: Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway

更正:对TRAIL诱导化合物的鉴定突显了小分子ONC201/TIC10作为一种独特的抗癌药物,它能够激活TRAIL通路。

Allen, Joshua E; Krigsfeld, Gabriel; Patel, Luv; Mayes, Patrick A; Dicker, David T; Wu, Gen Sheng; El-Deiry, Wafik S

Selective DRD2 antagonist and ClpP agonist ONC201 in a recurrent non-midline H3 K27M-mutant glioma cohort

选择性 DRD2 拮抗剂和 ClpP 激动剂 ONC201 在复发性非中线 H3 K27M 突变型胶质瘤队列中的应用

Odia, Yazmin; Hall, Matthew D; Cloughesy, Timothy Francis; Wen, Patrick Y; Arrillaga-Romany, Isabel; Daghistani, Doured; Mehta, Minesh P; Tarapore, Rohinton S; Ramage, Samuel C; Allen, Joshua E

Safety and pharmacokinetics of ONC201 (dordaviprone) administered two consecutive days per week in pediatric patients with H3 K27M-mutant glioma

在患有 H3 K27M 突变型胶质瘤的儿科患者中,每周连续两天服用 ONC201(多达韦普隆)的安全性和药代动力学研究

Odia, Yazmin; Koschmann, Carl; Vitanza, Nicholas A; de Blank, Peter; Aguilera, Dolly; Allen, Jeffrey; Daghistani, Doured; Hall, Matthew; Khatib, Ziad; Kline, Cassie; MacDonald, Tobey; Mueller, Sabine; Faison, Shamia L; Allen, Joshua E; Naderer, Odin J; Ramage, Samuel C; Tarapore, Rohinton S; McGovern, Susan Lynne; Khatua, Soumen; Zaky, Wafik; Gardner, Sharon L