Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis
靶向 Aurora B 激酶可通过增强 BIM 和 PUMA 介导的细胞凋亡来预防和克服肺癌对 EGFR 抑制剂的耐药性。
期刊:Cancer Cell
影响因子:48.8
doi:10.1016/j.ccell.2021.07.006
Kosuke Tanaka,Helena A Yu,Shaoyuan Yang,Song Han,S Duygu Selcuklu,Kwanghee Kim,Shriram Ramani,Yogesh Tengarai Ganesan,Allison Moyer,Sonali Sinha,Yuchen Xie,Kota Ishizawa,Hatice U Osmanbeyoglu,Yang Lyu,Nitin Roper,Udayan Guha,Charles M Rudin,Mark G Kris,James J Hsieh,Emily H Cheng
肺癌
细胞生物学
肿瘤
表观遗传
EGF
EGFR
RORA
Apoptosis
凋亡
