Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier
PF-5274857 是一种强效且具有选择性的 Smoothened 拮抗剂，能够穿透血脑屏障，有效靶向髓母细胞瘤模型中的 Hedgehog 信号传导
期刊:Molecular Cancer Therapeutics
影响因子:5.3
doi:10.1158/1535-7163.MCT-11-0691
Allison Rohner, Mary E Spilker, Justine L Lam, Bernadette Pascual, Darian Bartkowski, Qing John Li, Amy H Yang, Greg Stevens, Meirong Xu, Peter A Wells, Simon Planken, Sajiv Nair, Shaoxian Sun
