Multi-omics liquid biopsy identifies mitochondrial dysfunction in geographic atrophy and supports the longevity-associated metabolite α-ketoglutarate as a therapeutic strategy
多组学液体活检可识别地图状萎缩中的线粒体功能障碍,并支持将与长寿相关的代谢物α-酮戊二酸作为一种治疗策略。
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doi:10.64898/2026.03.12.26347263
Yeh, Tsai-Chu; Velez, Gabriel; Prasad, Architesh; Lee, Soo Hyeon; Rasmussen, Ditte K; Kumar, Aarushi; Chadha, Madhumeeta; Dabaja, Mohamed Ziad; Singh, Aneal M; Sanislo, Steven; Smith, Stephen; Mryuthyunjaya, Prithvi; Montague, Artis; Bassuk, Alexander G; Almeida, David; Dufour, Antoine; Mahajan, Vinit B