日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Microbiota-induced T cell plasticity enables immune-mediated tumour control.

微生物群诱导的T细胞可塑性能够实现免疫介导的肿瘤控制。

Najar Tariq A, Hao Yuan, Hao Yuhan, Romero-Meza Gabriela, Dolynuk Alexandra, Almo Emma, Littman Dan R

CD5L:p40, a novel heterodimeric regulator of type 2 inflammation

CD5L:p40,一种新型的2型炎症异二聚体调节因子

Wang, Chao; Zaghouani, Sarah; Wallrapp, Antonia; Newcomer, Kathleen; Greenfield, Edward; Johnson, Jacob Boyd; Barilla, Rocky; Pawlak, Mathias; Christian, Elena; Burkett, Patrick R; Leabo, Max; Li, Ping; Soto, Hortensia; Chen, Rena S; Monell, Craig; Brown, Marion H; Almo, Steven C; Singer, Meromit; Regev, Aviv; Kuchroo, Vijay K

Design of high-affinity binders to immune modulating receptors for cancer immunotherapy

设计与免疫调节受体具有高亲和力的结合剂用于癌症免疫治疗

Wei Yang ,Derrick R Hicks ,Agnidipta Ghosh ,Tristin A Schwartze ,Brian Conventry ,Inna Goreshnik ,Aza Allen ,Samer F Halabiya ,Chan Johng Kim ,Cynthia S Hinck ,David S Lee ,Asim K Bera ,Zhe Li ,Yujia Wang ,Thomas Schlichthaerle ,Longxing Cao ,Buwei Huang ,Sarah Garrett ,Stacey R Gerben ,Stephen Rettie ,Piper Heine ,Analisa Murray ,Natasha Edman ,Lauren Carter ,Lance Stewart ,Steven C Almo ,Andrew P Hinck ,David Baker

Structural basis for sensitivity and acquired resistance of fungal cap guanine-N7 methyltransferases to the antifungal antibiotic sinefungin

真菌帽鸟嘌呤-N7甲基转移酶对抗菌抗生素西尼芬净的敏感性和获得性耐药性的结构基础

Nilson, Daniel J; Schwer, Beate; Almo, Steven C; Shuman, Stewart; Ghosh, Agnidipta

Unique mechanisms to increase structural stability and enhance antigen binding in nanobodies

纳米抗体中提高结构稳定性和增强抗原结合的独特机制

Natalia E Ketaren,Peter C Fridy,Vladimir Malashkevich,Tanmoy Sanyal,Marc Brillantes,Mary K Thompson,Deena A Oren,Jeffrey B Bonanno,Andrej Šali,Steven C Almo,Brian T Chait,Michael P Rout

T-cell receptor/CD28-targeted immunotherapeutics selectively drive naive T-cell expansion to generate functional HIV-specific responses

靶向T细胞受体/CD28的免疫疗法可选择性地促进初始T细胞扩增,从而产生功能性的HIV特异性免疫应答。

April L Mueller ,Sara Lamcaj ,Scott Garforth ,Christopher Hiner ,Darien Woodley ,Kitt Paraiso ,Tian Mi ,Simon Low ,Ben Youngblood ,Steven C Almo ,Harris Goldstein

Discovery of a Biotin Synthase That Utilizes an Auxiliary 4Fe-5S Cluster for Sulfur Insertion

发现一种利用辅助性 4Fe-5S 簇进行硫插入的生物素合成酶

Lachowicz, Jake C; Lennox-Hvenekilde, David; Myling-Petersen, Nils; Salomonsen, Bo; Verkleij, Gijs; Acevedo-Rocha, Carlos G; Caddell, Ben; Gronenberg, Luisa S; Almo, Steven C; Sommer, Morten O A; Genee, Hans J; Grove, Tyler L

A hemoprotein with a zinc-mirror heme site ties heme availability to carbon metabolism in cyanobacteria

蓝藻中一种具有锌镜像血红素位点的血红素蛋白将血红素的可用性与碳代谢联系起来。

Nicolas Grosjean,Estella F Yee,Desigan Kumaran,Kriti Chopra,Macon Abernathy,Sandeep Biswas,James Byrnes,Dale F Kreitler,Jan-Fang Cheng,Agnidipta Ghosh,Steven C Almo,Masakazu Iwai,Krishna K Niyogi,Himadri B Pakrasi,Ritimukta Sarangi,Hubertus van Dam,Lin Yang,Ian K Blaby,Crysten E Blaby-Haas

Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes

与 1 型糖尿病差异相关的高度相似 HLA-B 同种型的结构和生化分析

Ruby Sharma, Nitin P Amdare, Agnidipta Ghosh, Jennifer Schloss, John Sidney, Scott J Garforth, Yessenia Lopez, Alev Celikgil, Alessandro Sette, Steven C Almo, Teresa P DiLorenzo

Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients

整合分子结构解析及构建与新冠肺炎患者古老先天免疫反应相关的扩展代谢通路

Samuele Sala ,Philipp Nitschke ,Reika Masuda ,Nicola Gray ,Nathan G Lawler ,James M Wood ,Joshua N Buckler ,Georgy Berezhnoy ,Jose Bolaños ,Berin A Boughton ,Caterina Lonati ,Titus Rössler ,Yogesh Singh ,Ian D Wilson ,Samantha Lodge ,Aude-Claire Morillon ,Ruey Leng Loo ,Drew Hall ,Luke Whiley ,Gary B Evans ,Tyler L Grove ,Steven C Almo ,Lawrence D Harris ,Elaine Holmes ,Uta Merle ,Christoph Trautwein ,Jeremy K Nicholson ,Julien Wist