Tryptophan metabolites 3-hydroxykynurenine (3HK) and 3-hydroxyanthranilic acid (3HAA) increase oxidative stress and impair osteoblastic bone formation.
色氨酸代谢产物 3-羟基犬尿氨酸 (3HK) 和 3-羟基邻氨基苯甲酸 (3HAA) 会增加氧化应激并损害成骨细胞的骨形成。
期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2026.111174
Alhamad Dima W, Bensreti Husam, Ding Kehong, Sultana Shabiha, Yearwood Christopher L, Ellingwood Ashley, Shaver Joseph, Burkhart Kyle, Tripathi Alok, Dorn Jennifer, Cushing Michaela, Nesbit Hima, Dai Caihong, Morey Eric, Gross Colby, Alhamad Miar, Taylor Dylan, Cherezova Alena, Ilatovskaya Daria V, Zhi Wenbo, Cooley Marion A, Zhong Roger, Johnson Maribeth H, Bollag Wendy B, Hamrick Mark W, Fulzele Sadanand, Hill William D, Isales Carlos M, McGee-Lawrence Meghan E