日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Small molecule screening identifies cytotoxic endoplasmic reticulum-associated degradation inhibitors in multiple myeloma

小分子筛选在多发性骨髓瘤中鉴定出细胞毒性内质网相关降解抑制剂

期刊:Cell Death & Disease
影响因子:9.6
doi:10.1038/s41419-026-08526-2
Kropp, Erin M; Matono, Sho; Wang, Olivia Y; Robida, Aaron M; Kandarpa, Malathi; Grant, Jineigh L; Oleson, Bryndon J; Alt, Andrew; Talpaz, Moshe; Pianko, Matthew J; Li, Qing
多发性骨髓瘤
细胞生物学
毒理研究
骨髓瘤
发表日期：2026
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High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase.

高通量筛选发现了一种新型的 Hsp70 小分子调节剂，该调节剂可选择性地增强错误折叠的神经元 NO 合酶的泛素化和降解

期刊:Molecular Pharmacology
影响因子:3
doi:10.1016/j.molpha.2024.100008
Garcia Anthony M, Davis Amanda K, Martinez-Ramos Cristian, Morishima Yoshihiro, Lau Miranda, Xu Emily, Sunil Arya, Zhang Haoming, Alt Andrew, Lieberman Andrew P, Osawa Yoichi
神经科学
泛素化
发表日期：2025
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Identification of Omaveloxolone as An Endoplasmic Reticulum Associated Degradation Inhibitor That Induces Early Apoptotic Signaling in Multiple Myeloma

鉴定出奥马维洛酮是一种内质网相关降解抑制剂，可诱导多发性骨髓瘤早期凋亡信号传导

期刊:
影响因子:
doi:10.1101/2025.04.02.646787
Kropp, Erin M; Matono, Sho; Wang, Olivia Y; Robida, Aaron M; Kandarpa, Malathi; Grant, Jineigh L; Oleson, Bryndon J; Alt, Andrew; Talpaz, Moshe; Pianko, Matthew; Li, Qing
信号转导
凋亡
表观遗传
多发性骨髓瘤
骨髓瘤
发表日期：2025
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N-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels.

N-(4-溴-2,5-二甲氧基苯乙基)-6-(4-苯基丁氧基)己烷-1-胺 (XOB)：一种新型的血清素 2A 受体和电压门控钠通道的苯烷基胺拮抗剂

期刊:Molecular Pharmacology
影响因子:3
doi:10.1124/molpharm.123.000837
Denomme Nicholas, Hernandez Ciria C, Bock Hailey A, Ohana Rachel F, Bakshi Shreeya, Sherwood Alexander M, McCorvy John D, Daley Paul F, Callaway Wyeth B, Hull Jacob M, Alt Andrew, Isom Lori L, Cozzi Nicholas V
信号转导
发表日期：2024
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Finding the Perfect Fit: Conformational Biosensors to Determine the Efficacy of GPCR Ligands

寻找最佳匹配：构象生物传感器在确定GPCR配体效力中的应用

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.1c00256
Olson, Keith M; Campbell, Andra; Alt, Andrew; Traynor, John R
GPCR/Calcium/cAMP
发表日期：2022
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Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects

μ-阿片受体的正向变构调节可产生镇痛作用，且副作用较少

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2000017118
Kandasamy, Ram; Hillhouse, Todd M; Livingston, Kathryn E; Kochan, Kelsey E; Meurice, Claire; Eans, Shainnel O; Li, Ming-Hua; White, Andrew D; Roques, Bernard P; McLaughlin, Jay P; Ingram, Susan L; Burford, Neil T; Alt, Andrew; Traynor, John R
信号转导
发表日期：2021
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Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators

变构调节剂先导化合物隐藏在显眼位置：开发肽和拟肽作为GPCR变构调节剂

期刊:Frontiers in Chemistry
影响因子:4.2
doi:10.3389/fchem.2021.671483
Olson, Keith M; Traynor, John R; Alt, Andrew
GPCR/Calcium/cAMP
发表日期：2021
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Discovery of Selective Cannabinoid CB(2) Receptor Agonists by High-Throughput Screening

利用高通量筛选发现选择性大麻素CB(2)受体激动剂

期刊:SLAS Discovery
影响因子:2.7
doi:10.1177/2472555217748403
Ogawa, Lisa M; Burford, Neil T; Liao, Yu-Hsien; Scott, Caitlin E; Hine, Ashley M; Dowling, Craig; Chin, Jefferson; Power, Mike; Hunnicutt, Edward J Jr; Emerick, Victoria L; Banks, Martyn; Zhang, Litao; Gerritz, Samuel W; Alt, Andrew; Kendall, Debra A
信号转导
发表日期：2018
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Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors

阿片受体正向变构调节剂的结合和作用机制的推测

期刊:ACS Chemical Biology
影响因子:3.8
doi:10.1021/acschembio.5b00712
Shang, Yi; Yeatman, Holly R; Provasi, Davide; Alt, Andrew; Christopoulos, Arthur; Canals, Meritxell; Filizola, Marta
信号转导
发表日期：2016
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