日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Humanization of antibodies using heavy chain complementarity-determining region 3 grafting coupled with in vitro somatic hypermutation

利用重链互补决定区 3 移植结合体外体细胞超突变实现抗体人源化

Peter M Bowers, Tamlyn Y Neben, Geoffery L Tomlinson, Jennifer L Dalton, Larry Altobell, Xue Zhang, John L Macomber, Betty F Wu, Rachelle M Toobian, Audrey D McConnell, Petra Verdino, Betty Chau, Robert A Horlick, David J King

High affinity humanized antibodies without making hybridomas; immunization paired with mammalian cell display and in vitro somatic hypermutation

无需制备杂交瘤即可获得高亲和力人源化抗体;免疫与哺乳动物细胞展示和体外体细胞超突变相结合

Audrey D McConnell, Minjee Do, Tamlyn Y Neben, Vladimir Spasojevic, Josh MacLaren, Andy P Chen, Laurence Altobell 3rd, John L Macomber, Ashley D Berkebile, Robert A Horlick, Peter M Bowers, David J King

Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies

将哺乳动物细胞表面展示与体细胞超突变相结合以发现和成熟人类抗体

Peter M Bowers, Robert A Horlick, Tamlyn Y Neben, Rachelle M Toobian, Geoffrey L Tomlinson, Jennifer L Dalton, Heather A Jones, Andy Chen, Laurence Altobell 3rd, Xue Zhang, John L Macomber, Irina P Krapf, Betty F Wu, Audrey McConnell, Betty Chau, Trevin Holland, Ashley D Berkebile, Steven S Neben, W

Antibody interference with N-acyl homoserine lactone-mediated bacterial quorum sensing

抗体干扰N-酰基高丝氨酸内酯介导的细菌群体感应

Kaufmann, Gunnar F; Sartorio, Rafaella; Lee, Sang-Hyeup; Mee, Jenny M; Altobell, Laurence J 3rd; Kujawa, David P; Jeffries, Emily; Clapham, Bruce; Meijler, Michael M; Janda, Kim D