日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

From nicotine to SARS-CoV-2 antivirals with potent in vivo efficacy and a broad anti-coronavirus spectrum

从尼古丁到具有强效体内疗效和广谱抗冠状病毒作用的SARS-CoV-2抗病毒药物

Khatua, Kaustav; Atla, Sandeep; Coleman, Demonta; Blankenship, Lauren R; Alugubelli, Yugendar R; Vulupala, Veerabhadra; Guo, Xuejiao Shirley; Xia, Hongjie; Kalveram, Birte K; Walker, David H; Hurst, Brett L; Kumar, Sathish; Cho, Chia-Chuan D; Sharma, Shivangi; Yang, Kai; Rabie, Dorsa; Nyalata, Satyanarayana; Neuman, Benjamin W; Xie, Xuping; Xu, Shiqing; Liu, Wenshe Ray

The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma

功能性转录组图谱为多发性骨髓瘤的治疗策略提供信息

Sudalagunta, Praneeth Reddy; Canevarolo, Rafael R; Meads, Mark B; Silva, Maria; Zhao, Xiaohong; Cubitt, Christopher L; Sansil, Samer S; DeAvila, Gabriel; Alugubelli, Raghunandan Reddy; Bishop, Ryan T; Tungesvik, Alexandre; Zhang, Qi; Hampton, Oliver; Teer, Jamie K; Welsh, Eric A; Yoder, Sean J; Shah, Bijal D; Hazlehurst, Lori; Gatenby, Robert A; Van Domelen, Dane R; Chai, Yi; Wang, Feng; DeCastro, Andrew; Bloomer, Amanda M; Siegel, Erin M; Lynch, Conor C; Sullivan, Daniel M; Alsina, Melissa; Nishihori, Taiga; Brayer, Jason; Cleveland, John L; Dalton, William; Walker, Christopher J; Landesman, Yosef; Baz, Rachid; Silva, Ariosto S; Shain, Kenneth H

Ubiquitin Azapeptide Esters as Next-Generation Activity-Based Probes for Cysteine Enzymes in the Ubiquitin Signal Pathway

泛素氮杂肽酯作为泛素信号通路中半胱氨酸酶的新一代活性探针

Chanda, Saibal; Atla, Sandeep; Sheng, Xinlei; Nyalata, Satyanarayana; Alugubelli, Yugendar R; Coleman, Demonta D; Jiang, Wen; Lopes, Rosana; Guo, Shaodong; Wand, A Joshua; Zhao, Yingming; Liu, Wenshe Ray

Acid ceramidase controls proteasome inhibitor resistance and is a novel therapeutic target for the treatment of relapsed/refractory multiple myeloma

酸性神经酰胺酶控制蛋白酶体抑制剂耐药性,是治疗复发/难治性多发性骨髓瘤的新型治疗靶点。

Bishop, Ryan T; Li, Tao; Sudalagunta, Praneeth; Nasr, Mostafa; Nyman, Karl J; Alugubelli, Raghunandan R; Meads, Mark; Frieling, Jeremy; Nerlakanti, Niveditha; Tauro, Marilena; Fang, Bin; Grant, Steven; Koomen, John; Silva, Ariosto S; Shain, Kenneth H; Lynch, Conor C

Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple Myeloma.

表观遗传可塑性驱动多发性骨髓瘤的致癌作用和多重治疗耐药性

Renatino Canevarolo Rafael, Sudalagunta Praneeth Reddy, Meads Mark B, Silva Maria, Zhao Xiaohong, Magaletti Dario, Alugubelli Raghunandan Reddy, DeAvila Gabriel, Persi Erez, Maura Francesco, Bell Elissa T, Bishop Ryan T, Cubitt Christopher L, Sansil Samer S, Zhang Wei, Teer Jamie K, Teng Mingxiang, Yoder Sean J, Siegel Erin M, Shah Bijal D, Nishihori Taiga, Hazlehurst Lori A, Lynch Conor C, Landgren Ola, Hampton Oliver, Gatenby Robert A, Sullivan Daniel M, Brayer Jason B, Dalton William S, Cleveland John L, Alsina Melissa, Baz Rachid, Shain Kenneth H, Silva Ariosto Siqueira

Unc-51 Like Kinase 3 (ULK3) is essential for autophagy and cell survival in multiple myeloma.

Unc-51 样激酶 3 (ULK3) 对多发性骨髓瘤的自噬和细胞存活至关重要

Tauro Marilena, Li Tao, Sudalagunta Praneeth R, Meads Mark, Canevarolo Rafael Renatino, Nerlakanti Niveditha, Alugubelli Raghunandan R, Lawrence Harshani R, Gunawan Steven, Ayaz Mohammad, Nareddy Pradeep, Yun Sang Young, Shay Gemma, Yang Kathy, Tran Timothy H, Bishop Ryan T, Nasr Mostafa M, Lawrence Nicholas N J, Schönbrunn Ernst, Cleveland John L, Silva Ariosto S, Shain Kenneth H, Lynch Conor C

Prioritization of Eleven-Nineteen-Leukemia Inhibitors as Orally Available Drug Candidates for Acute Myeloid Leukemia

优先筛选十一-十九白血病抑制剂作为急性髓系白血病口服候选药物

Xuejiao Shirley Guo ,Sandeep Atla ,Satyanarayana Nyalata ,Yugendar R Alugubelli ,Peng-Hsun Chase Chen ,Shiqing Xu ,Wenshe Ray Liu

Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease

发现首个 SARS-CoV-2 主蛋白酶 PROTAC 降解剂

Yugendar R Alugubelli, Jing Xiao, Kaustav Khatua, Sathish Kumar, Long Sun, Yuying Ma, Xinyu R Ma, Veerabhadra R Vulupala, Sandeep Atla, Lauren R Blankenship, Demonta Coleman, Xuping Xie, Benjamin W Neuman, Wenshe Ray Liu, Shiqing Xu

Combined MEK1/2 and ATR inhibition promotes myeloma cell death through a STAT3-dependent mechanism in vitro and in vivo

体外和体内实验均表明,MEK1/2 和 ATR 联合抑制可通过 STAT3 依赖性机制促进骨髓瘤细胞死亡。

Li, Lin; Hu, Xiaoyan; Nkwocha, Jewel; Kmieciak, Maciej; Meads, Mark B; Shain, Kenneth H; Alugubelli, Raghunandan R; Silva, Ariosto S; Mann, Hashim; Sudalagunta, Praneeth R; Canevarolo, Rafael R; Zhou, Liang; Grant, Steven

CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma

CK1δ 和 CK1ε 信号通路维持多发性骨髓瘤细胞的线粒体代谢和存活

Karen L Burger ,Mario R Fernandez ,Mark B Meads ,Praneeth Sudalagunta ,Paula S Oliveira ,Rafael Renatino Canevarolo ,Raghunandan Reddy Alugubelli ,Alexandre Tungsevik ,Gabe De Avila ,Maria Silva ,Allison I Graeter ,Hongyue A Dai ,Nicole D Vincelette ,Antony Prabhu ,Dario Magaletti ,Chunying Yang ,Weimin Li ,Amit Kulkarni ,Oliver Hampton ,John M Koomen ,William R Roush ,Andrii Monastyrskyi ,Anders E Berglund ,Ariosto S Silva ,John L Cleveland ,Kenneth H Shain