MicroRNA-130a is up-regulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription
MicroRNA-130a 在小鼠肝脏中因缺铁而上调,并靶向骨形态发生蛋白 (BMP) 受体 ALK2,以减弱 BMP 信号传导和铁调素转录
期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1074/jbc.M114.577387
Kimberly B Zumbrennen-Bullough, Qifang Wu, Amanda B Core, Susanna Canali, Wenjie Chen, Igor Theurl, Delphine Meynard, Jodie L Babitt