日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

SOS1抑制可增强KRASG12C抑制剂的疗效并延缓肺腺癌的耐药性。

Brianna R Daley ,Nancy E Sealover ,Bridget A Finniff ,Jacob M Hughes ,Erin Sheffels ,Daniel Gerlach ,Marco H Hofmann ,Kaja Kostyrko ,Joseph P LaMorte ,Amanda J Linke ,Zaria Beckley ,Andrew M Frank ,Robert E Lewis ,Matthew D Wilkerson ,Clifton L Dalgard ,Robert L Kortum

SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma

SOS2 调节 EGFR 信号阈值以调节奥希替尼在肺腺癌中的疗效和耐药性

Patricia L Theard, Amanda J Linke, Nancy E Sealover, Brianna R Daley, Johnny Yang, Katherine Cox, Robert L Kortum

Protocol for modeling acquired resistance to targeted therapeutics in adherent and suspension cancer cell lines via in situ resistance assay

通过原位抗性试验对粘附和悬浮癌细胞系中靶向治疗获得性抗性的建模协议

Nancy E Sealover, Jacob M Hughes, Patricia L Theard, Deepan Chatterjee, Amanda J Linke, Bridget A Finniff, Brianna R Daley, Robert E Lewis, Robert L Kortum

In situ modeling of acquired resistance to RTK/RAS-pathway-targeted therapies

RTK/RAS 通路靶向治疗获得性耐药的原位建模

Nancy E Sealover, Patricia T Theard, Jacob M Hughes, Amanda J Linke, Brianna R Daley, Robert L Kortum

SOS2 regulates the threshold of mutant EGFR-dependent oncogenesis

SOS2 调节突变 EGFR 依赖性肿瘤发生的阈值

Patricia L Theard, Amanda J Linke, Nancy E Sealover, Brianna R Daley, Johnny Yang, Katherine Cox, Robert L Kortum

STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer

肿瘤成纤维细胞中的STAT3促进胰腺癌免疫抑制微环境的形成

Julia E Lefler ,Catherine B MarElia-Bennett ,Katie A Thies ,Blake E Hildreth 3rd ,Sudarshana M Sharma ,Jason R Pitarresi ,Lu Han ,Caroline Everett ,Christopher Koivisto ,Maria C Cuitino ,Cynthia D Timmers ,Elizabeth O'Quinn ,Melodie Parrish ,Martin J Romeo ,Amanda J Linke ,G Aaron Hobbs ,Gustavo Leone ,Denis C Guttridge ,Teresa A Zimmers ,Gregory B Lesinski ,Michael C Ostrowski

Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

NSCLC 球体中 EGFR 信号的垂直抑制产生显著的协同作用,表明 SOS1 是 EGFR 突变癌症的治疗靶点

Patricia L Theard, Erin Sheffels, Nancy E Sealover, Amanda J Linke, David J Pratico, Robert L Kortum