日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection

在急性SHIVAD8-EO感染期间,使用对Fcγ受体具有更高亲和力的广谱中和抗HIV-1单克隆抗体进行治疗。

Joana Dias,Giulia Fabozzi,Slim Fourati,Xuejun Chen,Cuiping Liu,David R Ambrozak,Amy Ransier,Farida Laboune,Jianfei Hu,Wei Shi,Kylie March,Anna A Maximova,Stephen D Schmidt,Jakob Samsel,Chloe A Talana,Keenan Ernste,Sung Hee Ko,Margaret E Lucas,Pierce E Radecki,Kristin L Boswell,Yoshiaki Nishimura,John-Paul Todd,Malcolm A Martin,Constantinos Petrovas,Eli A Boritz,Nicole A Doria-Rose,Daniel C Douek,Rafick-Pierre Sékaly,Jeffrey D Lifson,Mangaiarkarasi Asokan,Lucio Gama,John R Mascola,Amarendra Pegu,Richard A Koup

HIV broadly neutralizing antibody escapability drives the therapeutic efficacy of vectored immunotherapy

HIV 广泛中和抗体的逃逸能力推动了载体免疫治疗的治疗效果

Nicolas M S Galvez, Yi Cao, Adam D Nitido, Cailin E Deal, Christine L Boutros, Scott W MacDonald, Yentli E Soto Albrecht, Evan C Lam, Maegan L Sheehan, Dylan Parsons, Allen Z Lin, Martin J Deymier, Jacqueline M Brady, Benjamin Moon, Christopher B Bullock, Serah Tanno, Amarendra Pegu, Xuejun Chen, Cu

Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses

罕见的、趋同的抗体靶向茎螺旋结构,可广泛中和多种β冠状病毒

Cherrelle Dacon ,Linghang Peng ,Ting-Hui Lin ,Courtney Tucker ,Chang-Chun D Lee ,Yu Cong ,Lingshu Wang ,Lauren Purser ,Andrew J R Cooper ,Jazmean K Williams ,Chul-Woo Pyo ,Meng Yuan ,Ivan Kosik ,Zhe Hu ,Ming Zhao ,Divya Mohan ,Mary Peterson ,Jeff Skinner ,Saurabh Dixit ,Erin Kollins ,Louis Huzella ,Donna Perry ,Russell Byrum ,Sanae Lembirik ,Michael Murphy ,Yi Zhang ,Eun Sung Yang ,Man Chen ,Kwanyee Leung ,Rona S Weinberg ,Amarendra Pegu ,Daniel E Geraghty ,Edgar Davidson ,Benjamin J Doranz ,Iyadh Douagi ,Susan Moir ,Jonathan W Yewdell ,Connie Schmaljohn ,Peter D Crompton ,John R Mascola ,Michael R Holbrook ,David Nemazee ,Ian A Wilson ,Joshua Tan

Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency

双特异性抗体 CAP256.J3LS 靶向 V2-apex 和 CD4-结合位点,具有高广度和效力

Baoshan Zhang, Jason Gorman, Young D Kwon, Amarendra Pegu, Cara W Chao, Tracy Liu, Mangaiarkarasi Asokan, Michael F Bender, Tatsiana Bylund, Leland Damron, Deepika Gollapudi, Paula Lei, Yile Li, Cuiping Liu, Mark K Louder, Krisha McKee, Adam S Olia, Reda Rawi, Arne Schön, Shuishu Wang, Eun Sung Yang

Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain

通过减少可变域上的净正电荷来改善 HIV 中和 VRC01 类抗体的药代动力学

Young D Kwon, Amarendra Pegu, Eun Sung Yang, Baoshan Zhang, Michael F Bender, Mangaiarkarasi Asokan, Qingbo Liu, Krisha McKee, Bob C Lin, Tracy Liu, Mark K Louder, Reda Rawi, Mateo Reveiz, Andrew J Schaub, Chen-Hsiang Shen, Nicole A Doria-Rose, Paolo Lusso, John R Mascola, Peter D Kwong

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529

SARS-CoV-2 变异株(包括 B.1.1.529)强效抗体中和的结构基础

Tongqing Zhou # ,Lingshu Wang # ,John Misasi # ,Amarendra Pegu ,Yi Zhang ,Darcy R Harris ,Adam S Olia ,Chloe Adrienna Talana ,Eun Sung Yang ,Man Chen ,Misook Choe ,Wei Shi ,I-Ting Teng ,Adrian Creanga ,Claudia Jenkins ,Kwanyee Leung ,Tracy Liu ,Erik-Stephane D Stancofski ,Tyler Stephens ,Baoshan Zhang ,Yaroslav Tsybovsky ,Barney S Graham ,John R Mascola # ,Nancy J Sullivan # ,Peter D Kwong #

Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition

Epstein-Barr病毒gH/gL蛋白有多个易受病毒中和和融合抑制的位点。

Wei-Hung Chen ,JungHyun Kim ,Wei Bu ,Nathan L Board ,Yaroslav Tsybovsky ,Yanmei Wang ,Anna Hostal ,Sarah F Andrews ,Rebecca A Gillespie ,Misook Choe ,Tyler Stephens ,Eun Sung Yang ,Amarendra Pegu ,Caroline E Peterson ,Brian E Fisher ,John R Mascola ,Stefania Pittaluga ,Adrian B McDermott ,Masaru Kanekiyo ,M Gordon Joyce ,Jeffrey I Cohen

Potent anti-viral activity of a trispecific HIV neutralizing antibody in SHIV-infected monkeys

三特异性 HIV 中和抗体在 SHIV 感染猴中具有强效抗病毒活性

Amarendra Pegu, Ling Xu, Megan E DeMouth, Giulia Fabozzi, Kylie March, Cassandra G Almasri, Michelle D Cully, Keyun Wang, Eun Sung Yang, Joana Dias, Christine M Fennessey, Jason Hataye, Ronnie R Wei, Ercole Rao, Joseph P Casazza, Wanwisa Promsote, Mangaiarkarasi Asokan, Krisha McKee, Stephen D Schmi

Anti-viral efficacy of a next-generation CD4-binding site bNAb in SHIV-infected animals in the absence of anti-drug antibody responses

在缺乏抗药抗体反应的情况下,新一代 CD4 结合位点广谱中和抗体 (bNAb) 对 SHIV 感染动物的抗病毒功效

Sarah E Lovelace ,Sabrina Helmold Hait ,Eun Sung Yang ,Madison L Fox ,Cuiping Liu ,Misook Choe ,Xuejun Chen ,Elizabeth McCarthy ,John-Paul Todd ,Ruth A Woodward ,Richard A Koup ,John R Mascola ,Amarendra Pegu

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

针对多种高传染性SARS-CoV-2变种的超强效抗体

Lingshu Wang # ,Tongqing Zhou # ,Yi Zhang ,Eun Sung Yang ,Chaim A Schramm ,Wei Shi ,Amarendra Pegu ,Olamide K Oloniniyi ,Amy R Henry ,Samuel Darko ,Sandeep R Narpala ,Christian Hatcher ,David R Martinez ,Yaroslav Tsybovsky ,Emily Phung ,Olubukola M Abiona ,Avan Antia ,Evan M Cale ,Lauren A Chang ,Misook Choe ,Kizzmekia S Corbett ,Rachel L Davis ,Anthony T DiPiazza ,Ingelise J Gordon ,Sabrina Helmold Hait ,Tandile Hermanus ,Prudence Kgagudi ,Farida Laboune ,Kwanyee Leung ,Tracy Liu ,Rosemarie D Mason ,Alexandra F Nazzari ,Laura Novik ,Sarah O'Connell ,Sijy O'Dell ,Adam S Olia ,Stephen D Schmidt ,Tyler Stephens ,Christopher D Stringham ,Chloe Adrienna Talana ,I-Ting Teng ,Danielle A Wagner ,Alicia T Widge ,Baoshan Zhang ,Mario Roederer ,Julie E Ledgerwood ,Tracy J Ruckwardt ,Martin R Gaudinski ,Penny L Moore ,Nicole A Doria-Rose ,Ralph S Baric ,Barney S Graham ,Adrian B McDermott ,Daniel C Douek ,Peter D Kwong ,John R Mascola ,Nancy J Sullivan ,John Misasi #