日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids.

MEF2C自闭症患者hiPSC神经元和脑类器官中miRNA表达和兴奋失调

Trudler Dorit, Ghatak Swagata, Bula Michael, Parker James, Talantova Maria, Luevanos Melissa, Labra Sergio, Grabauskas Titas, Noveral Sarah Moore, Teranaka Mayu, Schahrer Emily, Dolatabadi Nima, Bakker Clare, Lopez Kevin, Sultan Abdullah, Patel Parth, Chan Agnes, Choi Yongwook, Kawaguchi Riki, Stankiewicz Pawel, Garcia-Bassets Ivan, Kozbial Piotr, Rosenfeld Michael G, Nakanishi Nobuki, Geschwind Daniel H, Chan Shing Fai, Lin Wei, Schork Nicholas J, Ambasudhan Rajesh, Lipton Stuart A

Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

可溶性α-突触核蛋白-抗体复合物激活hiPSC衍生小胶质细胞中的NLRP3炎症小体

Trudler, Dorit; Nazor, Kristopher L; Eisele, Yvonne S; Grabauskas, Titas; Dolatabadi, Nima; Parker, James; Sultan, Abdullah; Zhong, Zhenyu; Goodwin, Marshall S; Levites, Yona; Golde, Todd E; Kelly, Jeffery W; Sierks, Michael R; Schork, Nicholas J; Karin, Michael; Ambasudhan, Rajesh; Lipton, Stuart A

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models

PINK1的S-亚硝基化减弱了基于hiPSC的帕金森病模型中PINK1/Parkin依赖的线粒体自噬

Oh, Chang-Ki; Sultan, Abdullah; Platzer, Joseph; Dolatabadi, Nima; Soldner, Frank; McClatchy, Daniel B; Diedrich, Jolene K; Yates, John R 3rd; Ambasudhan, Rajesh; Nakamura, Tomohiro; Jaenisch, Rudolf; Lipton, Stuart A

Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation

高血糖和寡聚β-淀粉样蛋白通过异常蛋白S-亚硝基化的共同途径破坏突触。

Akhtar, Mohd Waseem; Sanz-Blasco, Sara; Dolatabadi, Nima; Parker, James; Chon, Kevin; Lee, Michelle S; Soussou, Walid; McKercher, Scott R; Ambasudhan, Rajesh; Nakamura, Tomohiro; Lipton, Stuart A

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

异常的蛋白质S-亚硝基化与神经退行性疾病的病理生理学有关。

Nakamura, Tomohiro; Prikhodko, Olga A; Pirie, Elaine; Nagar, Saumya; Akhtar, Mohd Waseem; Oh, Chang-Ki; McKercher, Scott R; Ambasudhan, Rajesh; Okamoto, Shu-ichi; Lipton, Stuart A

Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells

利用基因编程的人类胚胎干细胞衍生的神经祖细胞进行帕金森病细胞治疗的潜力

Ambasudhan, Rajesh; Dolatabadi, Nima; Nutter, Anthony; Masliah, Eliezer; Mckercher, Scott R; Lipton, Stuart A

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

Aβ诱导星形胶质细胞释放谷氨酸、激活突触外NMDA受体并导致突触丢失

Talantova, Maria; Sanz-Blasco, Sara; Zhang, Xiaofei; Xia, Peng; Akhtar, Mohd Waseem; Okamoto, Shu-ichi; Dziewczapolski, Gustavo; Nakamura, Tomohiro; Cao, Gang; Pratt, Alexander E; Kang, Yeon-Joo; Tu, Shichun; Molokanova, Elena; McKercher, Scott R; Hires, Samuel Andrew; Sason, Hagit; Stouffer, David G; Buczynski, Matthew W; Solomon, James P; Michael, Sarah; Powers, Evan T; Kelly, Jeffery W; Roberts, Amanda; Tong, Gary; Fang-Newmeyer, Traci; Parker, James; Holland, Emily A; Zhang, Dongxian; Nakanishi, Nobuki; Chen, H-S Vincent; Wolosker, Herman; Wang, Yuqiang; Parsons, Loren H; Ambasudhan, Rajesh; Masliah, Eliezer; Heinemann, Stephen F; Piña-Crespo, Juan C; Lipton, Stuart A

Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions

在特定条件下将成人成纤维细胞直接重编程为功能性神经元

Ambasudhan, Rajesh; Talantova, Maria; Coleman, Ronald; Yuan, Xu; Zhu, Saiyong; Lipton, Stuart A; Ding, Sheng

Reprogramming of human primary somatic cells by OCT4 and chemical compounds

利用OCT4和化学化合物对人类原代体细胞进行重编程

Zhu, Saiyong; Li, Wenlin; Zhou, Hongyan; Wei, Wanguo; Ambasudhan, Rajesh; Lin, Tongxiang; Kim, Janghwan; Zhang, Kang; Ding, Sheng

Late-onset autosomal dominant macular dystrophy with choroidal neovascularization and nonexudative maculopathy associated with mutation in the RDS gene

与RDS基因突变相关的晚发性常染色体显性遗传性黄斑营养不良伴脉络膜新生血管和非渗出性黄斑病变

Khani, Shahrokh C; Karoukis, Athanasios J; Young, Joyce E; Ambasudhan, Rajesh; Burch, Tracy; Stockton, Richard; Lewis, Richard Alan; Sullivan, Lori S; Daiger, Stephen P; Reichel, Elias; Ayyagari, Radha