Amurrio Elvis相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Correction to "Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties"

对“具有改进药理特性的强效、选择性吡咯并嘧啶PDE11A4抑制剂”的更正

期刊:ACS Medicinal Chemistry Letters

doi:10.1021/acsmedchemlett.6c00150

Mahmood, Shams Ul; Boddu, Rama Krishna; Eberhard, Jeremy; Hoffman, Charles S; Gordon, John; Colussi, Dennis; Childers, Wayne; Amurrio, Elvis; Danaher, Marie; Kelly, Michy P; Rotella, David P

发表日期：2026

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Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties

具有改进药理特性的高效、选择性吡咯并嘧啶类PDE11A4抑制剂

期刊:ACS Medicinal Chemistry Letters

doi:10.1021/acsmedchemlett.5c00756

Mahmood, Shams Ul; Boddu, Rama Krishna; Eberhard, Jeremy; Hoffman, Charles S; Gordon, John; Colussi, Dennis; Childers, Wayne; Amurrio, Elvis; Danaher, Marie; Kelly, Michy P; Rotella, David P

发表日期：2026

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Age-Related Increases in PDE11A4 Protein Expression Trigger Liquid-Liquid Phase Separation (LLPS) of the Enzyme That Can Be Reversed by PDE11A4 Small Molecule Inhibitors.

与年龄相关的 PDE11A4 蛋白表达增加会引发该酶的液-液相分离 (LLPS)，而 PDE11A4 小分子抑制剂可以逆转这一现象

影响因子:5.2

doi:10.3390/cells14120897

Amurrio Elvis, Patel Janvi H, Danaher Marie, Goodwin Madison, Kargbo Porschderek, Klimentova Eliska, Lin Sonia, Kelly Michy P

发表日期：2025

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First Demonstration of In Vivo PDE11A4 Target Engagement for Potential Treatment of Age-Related Memory Disorders

首次证实体内PDE11A4靶点结合可用于治疗与年龄相关的记忆障碍

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.4c01794

Mahmood, Shams Ul; Eberhard, Jeremy; Hoffman, Charles S; Colussi, Dennis; Gordon, John; Childers, Wayne; Amurrio, Elvis; Patel, Janvi; Kelly, Michy P; Rotella, David P

发表日期：2024

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