日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DNMT3A R882H Is Not Required for Disease Maintenance in Primary Human AML but Is Associated with Increased Leukemia Stem Cell Frequency

DNMT3A R882H突变并非原发性人类急性髓系白血病(AML)维持疾病状态所必需,但与白血病干细胞频率增加相关。

Thomas Köhnke #,Daiki Karigane #,Eleanor Hilgart,Amy C Fan,Kensuke Kayamori,Masashi Miyauchi,Cailin T Collins,Fabian P Suchy,Athreya Rangavajhula,Yang Feng,Yusuke Nakauchi,Eduardo Martinez-Montes,Jonas L Fowler,Kyle M Loh,Hiromitsu Nakauchi,Michael A Koldobskiy,Andrew P Feinberg,Ravindra Majeti

A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis

单细胞框架识别成人人类造血过程中功能和分子特征不同的多能祖细胞

Asiri Ediriwickrema ,Yusuke Nakauchi ,Amy C Fan ,Thomas Köhnke ,Xiaoyi Hu ,Bogdan A Luca ,YeEun Kim ,Sreejith Ramakrishnan ,Margaret Nakamoto ,Daiki Karigane ,Miles H Linde ,Armon Azizi ,Aaron M Newman ,Andrew J Gentles ,Ravindra Majeti

Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated Protein Associated with Aberrant Deubiquitination of H2AK119

人类 ASXL1 突变造血由与 H2AK119 异常去泛素化相关的截短蛋白驱动

Thomas Köhnke, Kevin A Nuno, Catherine C Alder, Eric J Gars, Paul Phan, Amy C Fan, Ravindra Majeti

DNMT3AR882H Is Not Required for Disease Maintenance in Primary Human AML, but Is Associated With Increased Leukemia Stem Cell Frequency

DNMT3AR882H 不是人类原发性 AML 疾病维持所必需的,但与白血病干细胞频率增加有关

Thomas Köhnke, Daiki Karigane, Eleanor Hilgart, Amy C Fan, Kensuke Kayamori, Masashi Miyauchi, Cailin T Collins, Fabian P Suchy, Athreya Rangavajhula, Yang Feng, Yusuke Nakauchi, Eduardo Martinez-Montes, Jonas L Fowler, Kyle M Loh, Hiromitsu Nakauchi, Michael A Koldobskiy, Andrew P Feinberg, Ravindr

RUNX1 loss renders hematopoietic and leukemic cells dependent on IL-3 and sensitive to JAK inhibition

RUNX1 缺失导致造血细胞和白血病细胞依赖 IL-3 并对 JAK 抑制敏感

Amy C Fan, Yusuke Nakauchi, Lawrence Bai, Armon Azizi, Kevin A Nuno, Feifei Zhao, Thomas Köhnke, Daiki Karigane, David Cruz-Hernandez, Andreas Reinisch, Purvesh Khatri, Ravindra Majeti

IDH1-mutant preleukemic hematopoietic stem cells can be eliminated by inhibition of oxidative phosphorylation

IDH1 突变的白血病前造血干细胞可以通过抑制氧化磷酸化而被消除

Niklas Landberg, Thomas Köhnke, Yang Feng, Yusuke Nakauchi, Amy C Fan, Miles H Linde, Daiki Karigane, Kelly Lim, Rahul Sinha, Luca Malcovati, Daniel Thomas, Ravindra Majeti