日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RYR2 deficient human model identifies calcium handling and metabolic dysfunction impacting pharmacological responses

RYR2 缺陷人类模型可识别影响药理反应的钙处理和代谢功能障碍

Linda Starnes, Andrew Hall, Damla Etal, Anna-Lina Cavallo, Piotr Grabowski, John Gallon, Michelle Kha, Ryan Hicks, Amy Pointon

Simultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics

通过非靶向代谢组学同时发现药物的命运和生化效应

Tara J Bowen, Andrew D Southam, Andrew R Hall, Ralf J M Weber, Gavin R Lloyd, Ruth Macdonald, Amanda Wilson, Amy Pointon, Mark R Viant

An Extensive Metabolomics Workflow to Discover Cardiotoxin-Induced Molecular Perturbations in Microtissues

广泛的代谢组学工作流程,用于发现心脏毒素在微组织中引起的分子扰动

Tara J Bowen, Andrew R Hall, Gavin R Lloyd, Ralf J M Weber, Amanda Wilson, Amy Pointon, Mark R Viant

On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

体外器官芯片模型定义时间药代动力学-药效学关系的潜力

Christopher W McAleer, Amy Pointon, Christopher J Long, Rocky L Brighton, Benjamin D Wilkin, L Richard Bridges, Narasimham Narasimhan Sriram, Kristin Fabre, Robin McDougall, Victorine P Muse, Jerome T Mettetal, Abhishek Srivastava, Dominic Williams, Mark T Schnepper, Jeff L Roles, Michael L Shuler, 

Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology

人类 3D 心脏微组织的特征描述和验证,用于评估心脏病理学的变化

Caroline R Archer, Rebecca Sargeant, Jayati Basak, James Pilling, Jennifer R Barnes, Amy Pointon

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

心脏非肌细胞表现出增强的药理功能,提示干细胞衍生的心肌细胞微组织具有收缩成熟度

Stephanie M Ravenscroft, Amy Pointon, Awel W Williams, Michael J Cross, James E Sidaway