Decitabine cytotoxicity is promoted by dCMP deaminase DCTD and mitigated by SUMO-dependent E3 ligase TOPORS
地西他滨的细胞毒性由 dCMP 脱氨酶 DCTD 促进,并由 SUMO 依赖性 E3 连接酶 TOPORS 减轻
期刊:EMBO Journal
影响因子:9.4
doi:10.1038/s44318-024-00108-2
Christopher J Carnie #, Maximilian J Götz #, Chloe S Palma-Chaundler #, Pedro Weickert, Amy Wanders, Almudena Serrano-Benitez, Hao-Yi Li, Vipul Gupta, Samah W Awwad, Christian J Blum, Matylda Sczaniecka-Clift, Jacqueline Cordes, Guido Zagnoli-Vieira, Giuseppina D'Alessandro, Sean L Richards, Nadia G