Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17
iRhom1 和 iRhom2 胞质结构域的缺失会促进蛋白酶 ADAM17 对 TNF 受体的脱落。
期刊:Science Signaling
影响因子:6.6
doi:10.1126/scisignal.aac5356
Maney, Sathish K; McIlwain, David R; Polz, Robin; Pandyra, Aleksandra A; Sundaram, Balamurugan; Wolff, Dorit; Ohishi, Kazuhito; Maretzky, Thorsten; Brooke, Matthew A; Evers, Astrid; Vasudevan, Ananda A Jaguva; Aghaeepour, Nima; Scheller, Jürgen; Münk, Carsten; Häussinger, Dieter; Mak, Tak W; Nolan, Garry P; Kelsell, David P; Blobel, Carl P; Lang, Karl S; Lang, Philipp A