Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study
单剂量DSM265(一种新型疟原虫二氢乳清酸脱氢酶抑制剂)对无并发症的恶性疟原虫或间日疟原虫感染患者的抗疟活性:一项概念验证性、开放标签的2a期研究
期刊:Lancet Infectious Diseases
影响因子:31
doi:10.1016/S1473-3099(18)30309-8
Llanos-Cuentas, Alejandro; Casapia, Martin; Chuquiyauri, Raúl; Hinojosa, Juan-Carlos; Kerr, Nicola; Rosario, Maria; Toovey, Stephen; Arch, Robert H; Phillips, Margaret A; Rozenberg, Felix D; Bath, Jade; Ng, Caroline L; Cowell, Annie N; Winzeler, Elizabeth A; Fidock, David A; Baker, Mark; Möhrle, Jörg J; Hooft van Huijsduijnen, Rob; Gobeau, Nathalie; Araeipour, Nada; Andenmatten, Nicole; Rückle, Thomas; Duparc, Stephan