日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Impact of antibody Fc engineering on translational pharmacology, and safety: insights from industry case studies

抗体Fc工程对转化药理学和安全性的影响:来自行业案例研究的启示

Brennan, Frank R; Polli, J Ryan; Sathish, Jean; Ramones, Melissa; Wolf, Babette; Schlothauer, Tilman; Peters, Shirley J; Maier, Curtis C; Ji, Changhua; Wensel, David L; Witcher, Derrick; Ryan, Patricia C; Manetz, T Scott; Flora, Adriano; Soper, Brian; Fogal, Birgit; Dzielak, Lindsey; Wang, Xiaoting; Shastri, Prathap Nagaraja; Price, Karen; Doyle, Michael; Sharda, Nidhi; Struthers, Mary; Brinkhaus, Maximilian; Balbino, Bianca; Stefanich, Eric; Honda, Masaki; Andersen, Jan Terje; Mitchell-Ryan, Shermaine; Humphreys, David P

Targeting the Neonatal Fc Receptor in Autoimmune Diseases: Pipeline and Progress

靶向新生儿Fc受体治疗自身免疫性疾病:研发管线及进展

Gjølberg, Torleif Tollefsrud; Mester, Simone; Calamera, Gaia; Telstad, Jenny Skjermo; Sandlie, Inger; Andersen, Jan Terje

Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation

IgG-FcRn复合物形成过程中,IgG抗体Fab结构域与人FcRn之间存在直接相互作用的鉴定

Trabjerg, Esben; Nilsen, Jeannette; Tollefsrud Gjølberg, Torleif; Andersen, Jan Terje; Leitner, Alexander; Rand, Kasper D

Enhanced plasma half-life and efficacy of engineered human albumin-fused GLP-1 despite enzymatic cleavage of its C-terminal end.

尽管工程化人血白蛋白融合的 GLP-1 的 C 端被酶切,但其血浆半衰期和疗效仍得到增强

Nilsen Jeannette, Aaen Kristin Hovden, Benjakul Sopisa, Ruso-Julve Fulgencio, Greiner Thomas Uwe, Bejan Daniela, Stensland Maria, Singh Sachin, Schlothauer Tilman, Sandlie Inger, Andersen Jan Terje

Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction.

利用 FcRn 与白蛋白-CpG 寡核苷酸共价缀合物结合,实现强效的 TLR9 免疫诱导

Pilati Diego, Agyei Eugene Kusi, Elkhashab Marwa, Fuchs Elisabeth, Nielsen Ian Helstrup, Bjerg Tobias Wang, Anthi Aina Karen, Jiménez-Reinoso Anaïs, Iversen Marie Beck, Pohl Layla, Narita Ryo, Frago Susana, Jakobsen Martin R, Andersen Jan Terje, Degn Søren E, Paludan Søren R, Alvarez-Vallina Luis, Howard Kenneth A

Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability

天然抗体和人工合成抗体的生物物理图谱可以量化抗体可开发性的可塑性。

Bashour, Habib; Smorodina, Eva; Pariset, Matteo; Zhong, Jahn; Akbar, Rahmad; Chernigovskaya, Maria; Lê Quý, Khang; Snapkow, Igor; Rawat, Puneet; Krawczyk, Konrad; Sandve, Geir Kjetil; Gutierrez-Marcos, Jose; Gutierrez, Daniel Nakhaee-Zadeh; Andersen, Jan Terje; Greiff, Victor

Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations

多发性硬化症患者对SARS-CoV-2 mRNA疫苗的体液免疫:上次利妥昔单抗输注后的时间以及首次零星重复接种疫苗的经验的相关性

König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, The Trung; Schikora-Rustad, Stine; Vaage, Eline Benno; Mygland, Åse; Wergeland, Stig; Aarseth, Jan; Aaberge, Ingeborg Aase S; Torkildsen, Øivind; Holmøy, Trygve; Berge, Tone; Myhr, Kjell-Morten; Harbo, Hanne Flinstad; Andersen, Jan Terje; Munthe, Ludvig Andre; Søraas, Arne; Celius, Elisabeth Gulowsen; Vaage, John Torgils; Lund-Johansen, Fridtjof; Nygaard, Gro Owren

Assessing developability early in the discovery process for novel biologics

在新型生物制剂的发现过程早期评估其可开发性

Fernández-Quintero, Monica L; Ljungars, Anne; Waibl, Franz; Greiff, Victor; Andersen, Jan Terje; Gjølberg, Torelif T; Jenkins, Timothy P; Voldborg, Bjørn Gunnar; Grav, Lise Marie; Kumar, Sandeep; Georges, Guy; Kettenberger, Hubert; Liedl, Klaus R; Tessier, Peter M; McCafferty, John; Laustsen, Andreas H

Pharmaceutical compounding and storage of faricimab in a syringe for intravitreal injection do not impair stability and bi-specific binding properties

将法瑞西单抗配制成药物并在注射器中储存用于玻璃体内注射不会损害其稳定性和双特异性结合特性。

Jørstad, Øystein Kalsnes; Foss, Stian; Gjølberg, Torleif Tollefsrud; Mester, Simone; Nyquist-Andersen, Mari; Sivertsen, Magne Sand; Fossum, Dag; Gleditsch, Espen; Moe, Morten Carstens; Andersen, Jan Terje

Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge

强大的TRIM21和补体依赖性细胞内抗病毒免疫需要IgG3铰链区。

Foss, Stian; Jonsson, Alexandra; Bottermann, Maria; Watkinson, Ruth; Lode, Heidrun E; McAdam, Martin B; Michaelsen, Terje E; Sandlie, Inger; James, Leo C; Andersen, Jan Terje