日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11-Mutant Tumors to Anti-PD-1 Immunotherapy.

TNG260 是一种小分子 CoREST 抑制剂,可使 STK11 突变肿瘤对 PD-1 抗肿瘤免疫疗法敏感。

Ahronian Leanne G, Sahu Soumyadip, Zhang Minjie, Patel Ayushi S, Geng Ke, Bhattacharya Reshmee, Falchook Gerald S, Goldman Jonathan W, Spira Alexander I, Punekar Salman R, Spigel David R, Wang Judy S, Skoulidis Ferdinandos, Stephens Janaye, Meynardie Mary, Powell Jaylen M, Lopez Alfonso, Ranieri Michela, Ploszaj Magdalena A, Tan Yi Jer, Lee Yeuan Ting, Yu Yi, Deng Jiehui, Chen Ting, McCarren Patrick, Tsai Alice, Hussain Suleman S, Doyon Brian, Amemiya Kenjie, Ermolieff Jacques, Shahagadkar Preksha, Das Nikitha M, Flynn Lauren R, Shields Julie A, Danielczyk Laney, McMillan Brian J, Mignault Andre, Meier Samuel R, Wu Hsin-Jung, Guerin David J, Whittington Douglas A, Min Chengyin, Sienczylo Iga, Maxwell John P, DiBenedetto Heather J, Watanabe Hideo, Haines Brian B, Huang Alan, Crystal Adam, Andersen Jannik N, Wu Xinyuan, Wong Kwok-Kin

LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers.

LIG1 是 BRCA1 突变癌症中的合成致死靶点

Martires Lauren Catherine M, Ahronian Leanne G, Pratt Charlotte B, Das Nikitha M, Zhang Xiaobin, Whittington Douglas A, Zhang Hongxiang, Shen Binzhang, Come Jon, McCarren Patrick, Liu Mu-Sen, Min Chengyin, Feng Tianshu, Jahic Haris, Ali Janid A, Aird Daniel R, Li Fang, Andersen Jannik N, Huang Alan, Mallender William D, Nicholson Hilary E

Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency.

TNG348 的特性:一种选择性变构 USP1 抑制剂,可与 PARP 抑制剂在同源重组缺陷肿瘤中发挥协同作用

Simoneau Antoine, Pratt Charlotte B, Wu Hsin-Jung, Rajeswaran Shreya S, Comer Charlotte Grace, Sudsakorn Sirimas, Zhang Wenhai, Liu Shangtao, Meier Samuel R, Choi Ashley H, Khendu Tenzing, Stowe Hannah, Shen Binzhang, Whittington Douglas A, Chen Yingnan, Yu Yi, Mallender William D, Feng Tianshu, Andersen Jannik N, Maxwell John P, Throner Scott

VRK1 Is a Synthetic-Lethal Target in VRK2-Deficient Glioblastoma

VRK1是VRK2缺陷型胶质母细胞瘤的合成致死靶点

Shields, Julie A; Meier, Samuel R; Bandi, Madhavi; Mulkearns-Hubert, Erin E; Hajdari, Nicole; Ferdinez, Maria Dam; Engel, Justin L; Silver, Daniel J; Shen, Binzhang; Zhang, Wenhai; Hubert, Christopher G; Mitchell, Kelly; Shakya, Sajina; Zhao, Shan-Chuan; Bejnood, Alborz; Zhang, Minjie; Tjin Tham Sjin, Robert; Wilker, Erik; Lathia, Justin D; Andersen, Jannik N; Chen, Yingnan; Li, Fang; Weber, Barbara; Huang, Alan; Emmanuel, Natasha

Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities

设计具有优异疗效且无全身毒性的BET抑制剂瓶刷状前药

Vohidov, Farrukh; Andersen, Jannik N; Economides, Kyriakos D; Shipitsin, Michail V; Burenkova, Olga; Ackley, James C; Vangamudi, Bhavatarini; Nguyen, Hung V-T; Gallagher, Nolan M; Shieh, Peyton; Golder, Matthew R; Liu, Jenny; Dahlberg, William K; Ehrlich, Deborah J C; Kim, Julie; Kristufek, Samantha L; Huh, Sung Jin; Neenan, Allison M; Baddour, Joelle; Paramasivan, Sattanathan; de Stanchina, Elisa; Kc, Gaurab; Turnquist, David J; Saucier-Sawyer, Jennifer K; Kopesky, Paul W; Brady, Samantha W; Jessel, Michael J; Reiter, Lawrence A; Chickering, Donald E; Johnson, Jeremiah A; Blume-Jensen, Peter

Cross-talk between chromatin acetylation and SUMOylation of tripartite motif-containing protein 24 (TRIM24) impacts cell adhesion.

染色质乙酰化与三方基序蛋白 24 (TRIM24) 的 SUMO 化之间的相互作用影响细胞粘附

Appikonda Srikanth, Thakkar Kaushik N, Shah Parantu K, Dent Sharon Y R, Andersen Jannik N, Barton Michelle C

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

基于结构的IACS-9571设计:一种选择性高亲和力双重TRIM24-BRPF1溴结构域抑制剂

Palmer, Wylie S; Poncet-Montange, Guillaume; Liu, Gang; Petrocchi, Alessia; Reyna, Naphtali; Subramanian, Govindan; Theroff, Jay; Yau, Anne; Kost-Alimova, Maria; Bardenhagen, Jennifer P; Leo, Elisabetta; Shepard, Hannah E; Tieu, Trang N; Shi, Xi; Zhan, Yanai; Zhao, Shuping; Barton, Michelle C; Draetta, Giulio; Toniatti, Carlo; Jones, Philip; Geck Do, Mary; Andersen, Jannik N

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

观察到的溴结构域柔性揭示了ATAD2与组蛋白肽和小分子配体相容的形式

Poncet-Montange, Guillaume; Zhan, Yanai; Bardenhagen, Jennifer P; Petrocchi, Alessia; Leo, Elisabetta; Shi, Xi; Lee, Gilbert R 4th; Leonard, Paul G; Geck Do, Mary K; Cardozo, Mario G; Andersen, Jannik N; Palmer, Wylie S; Jones, Philip; Ladbury, John E

Identification of direct target engagement biomarkers for kinase-targeted therapeutics

鉴定激酶靶向治疗的直接靶点结合生物标志物

Paweletz, Cloud P; Andersen, Jannik N; Pollock, Roy; Nagashima, Kumiko; Hayashi, Mansuo L; Yu, Shangshuan U; Guo, Hongbo; Bobkova, Ekaterina V; Xu, Zangwei; Northrup, Alan; Blume-Jensen, Peter; Hendrickson, Ronald C; Chi, An

Sensitive multiplexed analysis of kinase activities and activity-based kinase identification

激酶活性的灵敏多重分析和基于活性的激酶鉴定

Kubota, Kazuishi; Anjum, Rana; Yu, Yonghao; Kunz, Ryan C; Andersen, Jannik N; Kraus, Manfred; Keilhack, Heike; Nagashima, Kumiko; Krauss, Stefan; Paweletz, Cloud; Hendrickson, Ronald C; Feldman, Adam S; Wu, Chin-Lee; Rush, John; Villén, Judit; Gygi, Steven P