日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cystic fibrosis risk variants confer protection against inflammatory bowel disease

囊性纤维化风险变异可预防炎症性肠病

Yu, Mingrui; Zhang, Qian; Yuan, Kai; Sazonovs, Aleksejs; Stevens, Christine R; Fachal, Laura; Lamb, Christopher A; Anderson, Carl A; Daly, Mark J; Huang, Hailiang

Enhancing analytical sensitivity in upstream bioprocess using time-gated Raman spectroscopy

利用时间门控拉曼光谱提高上游生物工艺的分析灵敏度

Shaikat, Mahdi Mubin; Dhara, Venkata Gayatri; Drennen, James K 3rd; Dong, Guogang; Anderson, Carl A

Performance of deep-learning-based approaches to improve polygenic scores

基于深度学习的方法在提高多基因评分方面的性能

Kelemen, Martin; Xu, Yu; Jiang, Tao; Zhao, Jing Hua; Anderson, Carl A; Wallace, Chris; Butterworth, Adam; Inouye, Michael

Gene expression QTL mapping in stimulated iPSC-derived macrophages provides insights into common complex diseases

利用刺激诱导多能干细胞衍生的巨噬细胞进行基因表达数量性状位点(QTL)定位,可为常见复杂疾病的研究提供新的见解。

Panousis, Nikolaos I; El Garwany, Omar; Knights, Andrew; Rop, Jesse Cheruiyot; Kumasaka, Natsuhiko; Imaz, Maria; Boquete Vilarino, Lorena; Tsingene, Anthi; Tokolyi, Alex; Barnett, Alice; Gomez, Celine; Anderson, Carl A; Gaffney, Daniel J

Splicing QTL mapping in stimulated macrophages associates low-usage splice junctions with immune-mediated disease risk.

在受刺激的巨噬细胞中进行剪接 QTL 定位,发现低使用率的剪接连接与免疫介导的疾病风险相关

El Garwany Omar, Panousis Nikolaos I, Knights Andrew, Kumasaka Natsuhiko, Imaz Maria, Vilarino Lorena Boquete, Tsingene Anthi, Tokolyi Alex, Martin Cristina Cotobal, Alegbe Tobi, Krzak Monika, Raine Tim, Barnett Alice, Gomez Celine, Gaffney Daniel J, Anderson Carl A

Cell-type-resolved genetic regulatory variation shapes inflammatory bowel disease risk

细胞类型特异性的基因调控变异影响炎症性肠病风险

Alegbe, Tobi; Harris, Bradley T; Fachal, Laura; Ramirez-Navarro, Lucia; Tutert, Marcus; Krzak, Monika; Ghouraba, Mennatallah; Strickland, Michelle; Ozols, Matiss; Khoullar, Saniya; Khabirova, Eleonora; Panousis, Nikolaos I; Ochoa, David; Wana, Noor; Hu, May Xueqi; Skelton, Jason; Ostermayer, Jasmin; Cheam, Kimberley Ai Xian; Taylor, D Leland; Gu, Yong; Dawson, Claire; Thompson, Tina; Arestang, Kenneth; Nishad, Nilanga; Leonard, Steven; Iyer, Vivek; McIntyre, Rebecca E; Parkes, Miles; Wallace, Chris; Cotobal Martin, Cristina; Jones, Gareth-Rhys; Raine, Tim; Anderson, Carl A

Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci

原发性硬化性胆管炎遗传风险位点的精细定位和分子特征分析

Goode, Elizabeth C; Fachal, Laura; Panousis, Nikolaos; Moutsianas, Loukas; McIntyre, Rebecca E; Bai, Benjamin Yu Hang; Kawasaki, Norihito; Wittmann, Alexandra; Raine, Tim; Rushbrook, Simon M; Anderson, Carl A

Baseline Expression of Immune Gene Modules in Blood is Associated With Primary Response to Anti-TNF Therapy in Crohn's Disease Patients

血液中免疫基因模块的基线表达与克罗恩病患者对TNF抑制剂治疗的初始反应相关

Bai, Benjamin Y H; Reppell, Mark; Smaoui, Nizar; Waring, Jeffrey F; Pivorunas, Valerie; Guay, Heath; Lin, Simeng; Chanchlani, Neil; Bewshea, Claire; Goodhand, James R; Kennedy, Nicholas A; Ahmad, Tariq; Anderson, Carl A

shaPRS: Leveraging shared genetic effects across traits or ancestries improves accuracy of polygenic scores

shaPRS:利用性状或祖先之间共享的遗传效应来提高多基因评分的准确性

Kelemen, Martin; Vigorito, Elena; Fachal, Laura; Anderson, Carl A; Wallace, Chris

Defining predictors of responsiveness to advanced therapies in Crohn's disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine

确定克罗恩病和溃疡性结肠炎对先进疗法反应的预测因子:IBD-RESPONSE 和嵌套 CD-metaRESPONSE 前瞻性、多中心、观察性队列研究方案(精准医学)

Wyatt, Nicola J; Watson, Hannah; Anderson, Carl A; Kennedy, Nicholas A; Raine, Tim; Ahmad, Tariq; Allerton, Dean; Bardgett, Michelle; Clark, Emma; Clewes, Dawn; Cotobal Martin, Cristina; Doona, Mary; Doyle, Jennifer A; Frith, Katherine; Hancock, Helen C; Hart, Ailsa L; Hildreth, Victoria; Irving, Peter M; Iqbal, Sameena; Kennedy, Ciara; King, Andrew; Lawrence, Sarah; Lees, Charlie W; Lees, Robert; Letchford, Laura; Liddle, Trevor; Lindsay, James O; Maier, Rebecca H; Mansfield, John C; Marchesi, Julian R; McGregor, Naomi; McIntyre, Rebecca E; Ostermayer, Jasmin; Osunnuyi, Tolulope; Powell, Nick; Prescott, Natalie J; Satsangi, Jack; Sharma, Shriya; Shrestha, Tara; Speight, Ally; Strickland, Michelle; Wason, James Ms; Whelan, Kevin; Wood, Ruth; Young, Gregory R; Zhang, Xinyue; Parkes, Miles; Stewart, Christopher J; Jostins-Dean, Luke; Lamb, Christopher A