Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)
免疫调节剂来那度胺和泊马度胺通过调节 E3 泛素连接酶复合物 CRL4(CRBN) 诱导 T 细胞抑制因子 Ikaros 和 Aiolos 的降解，从而共同刺激 T 细胞。
期刊:British Journal of Haematology
影响因子:3.8
doi:10.1111/bjh.12708
Gandhi, Anita K; Kang, Jian; Havens, Courtney G; Conklin, Thomas; Ning, Yuhong; Wu, Lei; Ito, Takumi; Ando, Hideki; Waldman, Michelle F; Thakurta, Anjan; Klippel, Anke; Handa, Hiroshi; Daniel, Thomas O; Schafer, Peter H; Chopra, Rajesh
Aiolos
Ikaros
T细胞
细胞生物学
CRBN
免疫/内分泌
