日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation

Rab4A 介导的内体运输通过线粒体自噬、CD98 表达和犬尿氨酸敏感的 mTOR 激活来调控 T 细胞中的促炎性线粒体代谢。

Nick Huang # ,Thomas Winans # ,Brandon Wyman ,Zachary Oaks ,Tamas Faludi ,Gourav Choudhary ,Zhi-Wei Lai ,Joshua Lewis ,Miguel Beckford ,Manuel Duarte ,Daniel Krakko ,Akshay Patel ,Joy Park ,Tiffany Caza ,Mahsa Sadeghzadeh ,Laurence Morel ,Mark Haas ,Frank Middleton ,Katalin Banki ,Andras Perl

Adenosine receptor 2a agonists target mouse CD11c+T-bet+ B cells in infection and autoimmunity

腺苷受体 2a 激动剂靶向小鼠 CD11c+T-bet+ B 细胞以抵抗感染和自身免疫

Russell C Levack, Krista L Newell, Berenice Cabrera-Martinez, Justin Cox, Andras Perl, Sheldon I Bastacky, Gary M Winslow

Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice

肠道菌群介导的色氨酸代谢紊乱调节易患狼疮小鼠的CD4+ T细胞

Josephine Brown ,Georges Abboud ,Longhuan Ma ,Seung-Chul Choi ,Nathalie Kanda ,Leilani Zeumer-Spataro ,Jean Lee ,Weidan Peng ,Joy Cagmat ,Tamas Faludi ,Mansour Mohamadzadeh ,Timothy Garrett ,Laura Mandik-Nayak ,Alexander Chervonsky ,Andras Perl ,Laurence Morel

Renal mTORC1 activation is associated with disease activity and prognosis in lupus nephritis

肾脏 mTORC1 激活与狼疮性肾炎的疾病活动性和预后相关

Zhaomin Mao, Ying Tan, Juan Tao, Linlin Li, Hui Wang, Feng Yu, Andras Perl, Minghui Zhao

Double-Edged Sword: Interleukin-2 Promotes T Regulatory Cell Differentiation but Also Expands Interleukin-13- and Interferon-γ-Producing CD8+ T Cells via STAT6-GATA-3 Axis in Systemic Lupus Erythematosus

双刃剑:白细胞介素-2在系统性红斑狼疮中通过STAT6-GATA-3轴促进T调节细胞分化,但也扩增产生白细胞介素-13和干扰素-γ的CD8+ T细胞

Hiroshi Kato ,Andras Perl

Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation

狼疮相关的内源性逆转录病毒LTR多态性和表观遗传印记促进HRES-1/RAB4表达和mTOR激活

Aparna Godavarthy,Ryan Kelly,John Jimah,Miguel Beckford,Tiffany Caza,David Fernandez,Nick Huang,Manuel Duarte,Joshua Lewis,Hind J Fadel,Eric M Poeschla,Katalin Banki,Andras Perl

Measurement of Mitochondrial Mass by Flow Cytometry during Oxidative Stress

氧化应激过程中流式细胞术测量线粒体质量

Edward Doherty, Andras Perl

Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus-Prone Mice

狼疮易感小鼠的肝脏线粒体功能障碍和抗磷脂抗体产生先于疾病发作并对雷帕霉素产生反应

Zachary Oaks, Thomas Winans, Tiffany Caza, David Fernandez, Yuxin Liu, Steve K Landas, Katalin Banki, Andras Perl

Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin

全面的代谢组学分析揭示了系统性红斑狼疮中N-乙酰半胱氨酸反应性犬尿氨酸的积累:对雷帕霉素靶蛋白激活的意义

Andras Perl ,Robert Hanczko ,Zhi-Wei Lai ,Zachary Oaks ,Ryan Kelly ,Rebecca Borsuk ,John M Asara ,Paul E Phillips

HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE

HRES-1/Rab4 介导的 Drp1 耗竭会损害线粒体稳态,并成为 SLE 治疗的一个靶点

Tiffany N Caza, David R Fernandez, Gergely Talaber, Zachary Oaks, Mark Haas, Michael P Madaio, Zhi-Wei Lai, Gabriella Miklossy, Ram R Singh, Dmitriy M Chudakov, Walter Malorni, Frank Middleton, Katalin Banki, Andras Perl