Andrea Pfeifer相关文献与解析，生知库 | 链接生命科学的每一步

Efthymia Vokali ，Elodie Chevalier ，Nicolas Dreyfus ，Dorian Charmey ，Tania Melly ，Jacqueline Kocher ，Monisha Ratnam ，Andreia M Serra ，Thomas Jaquier ，Christophe Delgado ，Myriam Ravache ，Carlo Scialò ，Sara Cappelli ，Heiko Kroth ，Francesca Capotosti ，Ruth Luthi-Carter ，Tariq Afroz ，Madiha Derouazi ，Cristian C Constantinescu ，Harro Seelaar ，Emanuele Buratti ，Peter T Nelson ，Magdalini Polymenidou ，Andrea Pfeifer ，Marie Kosco-Vilbois ，Tamara Seredenina

神经科学

发表日期：2025

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A single dose of a vectorized mAb targeting TDP-43 potently inhibits the neuropathology in a model of ALS/FTD

单剂量靶向TDP-43的载体化单克隆抗体可有效抑制ALS/FTD模型中的神经病理学改变。

期刊:Molecular Therapy

影响因子:12.1

doi:10.1016/j.ymthe.2025.06.026

Greg Del Val ，Florence Gauye ，Mickaël Audrain ，Sébastien Menant ，Monisha Ratnam ，Elodie Chevalier ，Romain Ollier ，Daisy Bhatia ，Tamara Seredenina ，Tariq Afroz ，Andrea Pfeifer ，Marie Kosco-Vilbois ，Damien Nevoltris

Targeting the TDP-43 low complexity domain blocks spreading of pathology in a mouse model of ALS/FTD

针对 TDP-43 低复杂度结构域阻断 ALS/FTD 小鼠模型中的病理扩散

期刊:Acta Neuropathologica Communications

影响因子:6.2

doi:10.1186/s40478-024-01867-z

Elodie Chevalier #, Mickael Audrain #, Monisha Ratnam, Romain Ollier, Aline Fuchs, Kasia Piorkowska, Andrea Pfeifer, Marie Kosco-Vilbois, Tamara Seredenina, Tariq Afroz

Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework

利用替代的人类框架，通过破坏连续的正表面电位和减少电荷来改善抗体的药代动力学。

期刊:MAbs

影响因子:5.6

doi:10.1080/19420862.2023.2232087

Romain Ollier ,Aline Fuchs ,Florence Gauye ,Katarzyna Piorkowska ,Sébastien Menant ,Monisha Ratnam ,Paolo Montanari ,Florence Guilhot ,Didier Phillipe ,Mickael Audrain ,Anne-Laure Egesipe ,Damien Névoltris ,Tamara Seredenina ,Andrea Pfeifer ,Marie Kosco-Vilbois ,Tariq Afroz

发表日期：2023

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Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior

在 Ts65Dn 小鼠中模拟阿尔茨海默病相关表型：年龄对 Aβ、Tau、pTau、NfL 和行为的影响

期刊:Frontiers in Neuroscience

影响因子:3.2

doi:10.3389/fnins.2023.1202208

Cassia Overk, Emma Fiorini, Chiara Babolin, Marija Vukicevic, Catherine Morici, Rime Madani, Valerie Eligert, Marie Kosco-Vilbois, Amanda Roberts, Ann Becker, Andrea Pfeifer, William C Mobley

Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model

ACI-24疫苗接种对淀粉样变性小鼠模型中Aβ斑块病理和微胶质细胞表型的有益作用

期刊:Cells

影响因子:5.1

doi:10.3390/cells12010079

Jasenka Rudan Njavro ，Marija Vukicevic ，Emma Fiorini ，Lina Dinkel ，Stephan A Müller ，Anna Berghofer ，Chiara Bordier ，Stanislav Kozlov ，Annett Halle ，Katrin Buschmann ，Anja Capell ，Camilla Giudici ，Michael Willem ，Regina Feederle ，Stefan F Lichtenthaler ，Chiara Babolin ，Paolo Montanari ，Andrea Pfeifer ，Marie Kosco-Vilbois ，Sabina Tahirovic

Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies

发现 2-(4-(2-氟乙氧基)哌啶-1-基)-9-甲基-9H-吡咯并[2,3-b:4,5-c']二吡啶 ([18F]PI-2014) 作为 PET 示踪剂，用于检测阿尔茨海默病和其他 tau 蛋白病中的病理性聚集 tau

期刊:European Journal of Medicinal Chemistry

影响因子:6

doi:10.1016/j.ejmech.2020.112615

Emanuele Gabellieri, Francesca Capotosti, Jerome Molette, Nampally Sreenivasachary, Andre Mueller, Mathias Berndt, Hanno Schieferstein, Tanja Juergens, Yvan Varisco, Felix Oden, Heribert Schmitt-Willich, David Hickman, Ludger Dinkelborg, Andrew Stephens, Andrea Pfeifer, Heiko Kroth

Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies

发现并进行临床前表征 [18F]PI-2620，这是一种下一代 tau PET 示踪剂，可用于评估阿尔茨海默病和其他 tau 蛋白病中的 tau 病理

期刊:European Journal of Nuclear Medicine and Molecular Imaging

影响因子:8.6

doi:10.1007/s00259-019-04397-2

Heiko Kroth, Felix Oden, Jerome Molette, Hanno Schieferstein, Francesca Capotosti, Andre Mueller, Mathias Berndt, Heribert Schmitt-Willich, Vincent Darmency, Emanuele Gabellieri, Cédric Boudou, Tanja Juergens, Yvan Varisco, Efthymia Vokali, David T Hickman, Gilles Tamagnan, Andrea Pfeifer, Ludger Di

Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression

钙蛋白酶介导的 tau 碎片在阿尔茨海默病进展中发生改变

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-018-35130-y

Hsu-Hsin Chen, Peter Liu, Paul Auger, Seung-Hye Lee, Oskar Adolfsson, Lorianne Rey-Bellet, Julien Lafrance-Vanasse, Brad A Friedman, Maria Pihlgren, Andreas Muhs, Andrea Pfeifer, James Ernst, Gai Ayalon, Kristin R Wildsmith, Thomas G Beach, Marcel P van der Brug

Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope

使用脂质体疫苗生成的新型磷酸化 Tau 单克隆抗体，对构象 Tau 蛋白病表位的识别能力增强

期刊:Journal of Alzheimers Disease

影响因子:3.4

doi:10.3233/JAD-160695

Clara Theunis, Oskar Adolfsson, Natalia Crespo-Biel, Kasia Piorkowska, Maria Pihlgren, David T Hickman, Valérie Gafner, Peter Borghgraef, Herman Devijver, Andrea Pfeifer, Fred Van Leuven, Andreas Muhs

表观遗传

发表日期：2017

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Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology

[18F]ACI-19626 的开发：作为首个用于 TDP-43 病理成像的脑部 PET 示踪剂

A single dose of a vectorized mAb targeting TDP-43 potently inhibits the neuropathology in a model of ALS/FTD

单剂量靶向TDP-43的载体化单克隆抗体可有效抑制ALS/FTD模型中的神经病理学改变。

Targeting the TDP-43 low complexity domain blocks spreading of pathology in a mouse model of ALS/FTD

针对 TDP-43 低复杂度结构域阻断 ALS/FTD 小鼠模型中的病理扩散

Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework

利用替代的人类框架，通过破坏连续的正表面电位和减少电荷来改善抗体的药代动力学。

Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior

在 Ts65Dn 小鼠中模拟阿尔茨海默病相关表型：年龄对 Aβ、Tau、pTau、NfL 和行为的影响

Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model

ACI-24疫苗接种对淀粉样变性小鼠模型中Aβ斑块病理和微胶质细胞表型的有益作用

Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies

发现 2-(4-(2-氟乙氧基)哌啶-1-基)-9-甲基-9H-吡咯并[2,3-b:4,5-c']二吡啶 ([18F]PI-2014) 作为 PET 示踪剂，用于检测阿尔茨海默病和其他 tau 蛋白病中的病理性聚集 tau

Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies

发现并进行临床前表征 [18F]PI-2620，这是一种下一代 tau PET 示踪剂，可用于评估阿尔茨海默病和其他 tau 蛋白病中的 tau 病理

Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression

钙蛋白酶介导的 tau 碎片在阿尔茨海默病进展中发生改变

Novel Phospho-Tau Monoclonal Antibody Generated Using a Liposomal Vaccine, with Enhanced Recognition of a Conformational Tauopathy Epitope

使用脂质体疫苗生成的新型磷酸化 Tau 单克隆抗体，对构象 Tau 蛋白病表位的识别能力增强