日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection

非凋亡性 caspase-8 在严重 SARS-CoV-2 感染期间协调过度炎症反应中起着关键作用。

Stefanie M Bader ,Lena Scherer ,Reet Bhandari ,Allan J Motyer ,James P Cooney ,Liana Mackiewicz ,Merle Dayton ,Dylan Sheerin ,David V L Romero ,Jan Schaefer ,Jiyi Pang ,Siqi Chen ,Kael Schoffer ,Le Wang ,Xinyi Jin ,Daniel Batey ,Raymond K H Yip ,Ishrat Zaman ,Pradeep Rajasekhar ,Matthew J Gartner ,Stephen Wilcox ,Lachlan Whitehead ,Smitha Rose Georgy ,Ana Maluenda ,Kathryn C Davidson ,Cody C Allison ,Rory Bowden ,Kerstin Brinkmann ,Marie-Liesse Asselin-Labat ,Belinda Phipson ,Maria C Tanzer ,Marco J Herold ,Andre L Samson ,James E Vince ,Andreas Strasser ,Marc Pellegrini ,Marcel Doerflinger

MCL‑1 safeguards activated hair follicle stem cells to enable adult hair regeneration

MCL-1保护活化的毛囊干细胞,从而促进成人毛发再生。

Hui San Chin ,Jinming Cheng ,Shih Han Hsu ,Guo Guang Lum ,Maria Tk Zaldivia ,Sarmilla Nelameham ,Fusheng Guo ,Keerthana Mallavarapu ,Felicity C Jackling ,Jicheng Yang ,Jonathan S L Tan ,Prabha Sampath ,Nick Barker ,Gordon K Smyth ,Geoffrey J Lindeman ,Andreas Strasser ,Jane E Visvader ,Yunshun Chen ,Ting Chen ,Nai Yang Fu

Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation

转录组变化(包括p53失调)使DNMT3A突变细胞更容易发生转化。

Erin M Lawrence # ,Amali Cooray # ,Andrew J Kueh ,Martin Pal ,Lin Tai ,Alexandra L Garnham ,Connie S N Li-Wai-Suen ,Hannah Vanyai ,Quentin Gouil ,James Lancaster ,Sylvie Callegari ,Lauren Whelan ,Elizabeth Lieschke ,Annabella Thomas ,Andreas Strasser ,Yang Liao ,Wei Shi ,Andrew H Wei ,Marco J Herold

Putting the STING back into BH3-mimetic drugs for TP53-mutant blood cancers

将 STING 重新放入用于治疗 TP53 突变血癌的 BH3 模拟药物中

Sarah T Diepstraten, Yin Yuan, John E La Marca, Savannah Young, Catherine Chang, Lauren Whelan, Aisling M Ross, Karla C Fischer, Giovanna Pomilio, Rhiannon Morris, Angela Georgiou, Veronique Litalien, Fiona C Brown, Andrew W Roberts, Andreas Strasser, Andrew H Wei, Gemma L Kelly

Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses

全基因组 CRISPR 筛选确定了 ARRDC3 在 TRP53 介导的反应中的作用

John E La Marca, Brandon J Aubrey #, Bruce Yang #, Catherine Chang, Zilu Wang, Andrew Kueh, Lin Tai, Stephen Wilcox, Liz Milla, Susanne Heinzel, David Vremec, Lauren Whelan, Christina König, Deeksha Kaloni, Anne K Voss, Andreas Strasser, Sarah T Diepstraten, Marco J Herold, Gemma L Kelly2

Mouse models to investigate in situ cell fate decisions induced by p53

用于研究 p53 诱导的原位细胞命运决定的小鼠模型

Elizabeth Lieschke, Annabella F Thomas, Andrew Kueh, Georgia K Atkin-Smith, Pedro L Baldoni, John E La Marca, Savannah Young, Allan Shuai Huang, Aisling M Ross, Lauren Whelan, Deeksha Kaloni, Lin Tai, Gordon K Smyth, Marco J Herold, Edwin D Hawkins, Andreas Strasser #, Gemma L Kelly #

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis

转录调控因子 TFAP4 的缺失加速了 c-MYC 驱动的淋巴瘤形成

Margaret A Potts, Shinsuke Mizutani, Alexandra L Garnham, Connie S N Li Wai Suen, Andrew J Kueh, Lin Tai, Martin Pal, Andreas Strasser, Marco J Herold

Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs

缺乏促凋亡 BAX 的淋巴瘤细胞对靶向促存活 MCL-1 的 BH3 类似物具有很强的抵抗力,但对传统的 DNA 损伤药物仍然敏感

Sarah T Diepstraten, Savannah Young, John E La Marca, Zilu Wang, Ruth M Kluck, Andreas Strasser, Gemma L Kelly

The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

抗癌药物APR-246可以激活多种程序性细胞死亡过程来杀死恶性细胞

Zilu Wang, Huimin Hu, Luuk Heitink, Kelly Rogers, Yue You, Tao Tan, Connie Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T Diepstraten, Catherine Chang, Tianwei Chen, Diane Moujalled, Kate Sutherland, Guillaume Lessene, Oliver M Sieber, Jane Visvader, Gemma L Kelly, Andreas Strasser

Deletion of Gpatch2 does not alter Tnf expression in mice

Gpatch2 的缺失不会改变小鼠体内的 Tnf 表达

Destiny Dalseno, Holly Anderton, Andrew Kueh, Marco J Herold, John Silke, Andreas Strasser, Philippe Bouillet