日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A single-cell atlas to map sex-specific gene-expression changes in blood upon neurodegeneration

利用单细胞图谱绘制神经退行性疾病过程中血液中性别特异性基因表达变化

Grandke, Friederike; Fehlmann, Tobias; Kern, Fabian; Gate, David M; Wolff, Tobias William; Leventhal, Olivia; Channappa, Divya; Hirsch, Pascal; Wilson, Edward N; Meese, Eckart; Liu, Chuanyu; Shi, Quan; Flotho, Matthias; Li, Yongping; Chen, Cynthia; Yu, Yeya; Xu, Jiangshan; Junkin, Michael; Wang, Zhifeng; Wu, Tao; Liu, Longqi; Hou, Yong; Andreasson, Katrin I; Gansen, Jenny S; Mass, Elvira; Poston, Kathleen; Wyss-Coray, Tony; Keller, Andreas

Plasma Aβ(42)/Aβ(40) is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum

血浆Aβ(42)/Aβ(40)比值对早期脑淀粉样蛋白沉积敏感,并可预测阿尔茨海默病谱系中认知功能下降的风险。

Trelle, Alexandra N; Young, Christina B; Vossler, Hillary; Ramos Benitez, Javier; Cody, Karly A; Mendiola, Justin H; Swarovski, Michelle S; Guen, Yann Le; Feinstein, Igor; Butler, Robert R 3rd; Channappa, Divya; Romero, America; Park, Jennifer; Shahid-Besanti, Marian; Corso, Nicole K; Chau, Kelly; Smith, Amanda N; Skylar-Scott, Irina; Yutsis, Maya V; Fredericks, Carolyn A; Tian, Lu; Younes, Kyan; Kerchner, Geoffrey A; Deutsch, Gayle K; Davidzon, Guido A; Sha, Sharon J; Henderson, Victor W; Longo, Frank M; Greicius, Michael D; Wyss-Coray, Tony; Andreasson, Katrin I; Poston, Kathleen L; Wagner, Anthony D; Mormino, Elizabeth C; Wilson, Edward N

NAD(+) depletion drives age-related monocyte hyperinflammation after stroke and is reversed by nicotinamide riboside.

中风后,NAD(+) 耗竭会引发与年龄相关的单核细胞过度炎症,而烟酰胺核苷可以逆转这种炎症。

Cabrera Mica, Eastman Brent, Ennerfelt Hannah, Alsaadi Abrar I, Alexandrova Ludmila, Ay Yeonglong Albert, Huang Jolie, Wang Qian, Blacher Eran, McReynolds Melanie R, Andreasson Katrin I, Iweka Chinyere Agbaegbu

Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.

帕金森病的特征是维生素 B6 依赖性炎症犬尿氨酸通路功能障碍

Wilson Edward N, Umans Jacob, Swarovski Michelle S, Minhas Paras S, Mendiola Justin H, Midttun Øivind, Ulvik Arve, Shahid-Besanti Marian, Linortner Patricia, Mhatre Siddhita D, Wang Qian, Channappa Divya, Corso Nicole K, Tian Lu, Fredericks Carolyn A, Kerchner Geoffrey A, Plowey Edward D, Cholerton Brenna, Ueland Per M, Zabetian Cyrus P, Gray Nora E, Quinn Joseph F, Montine Thomas J, Sha Sharon J, Longo Frank M, Wolk David A, Chen-Plotkin Alice, Henderson Victor W, Wyss-Coray Tony, Wagner Anthony D, Mormino Elizabeth C, Aghaeepour Nima, Poston Kathleen L, Andreasson Katrin I

(18)F-PI-2620 Tau PET is associated with cognitive and motor impairment in Lewy body disease

(18)F-PI-2620 Tau PET 与路易体病患者的认知和运动障碍相关

Winer, Joseph R; Vossler, Hillary; Young, Christina B; Smith, Viktorija; Romero, America; Shahid-Besanti, Marian; Abdelnour, Carla; Wilson, Edward N; Anders, David; Pacheco Morales, Aimara; Andreasson, Katrin I; Yutsis, Maya V; Henderson, Victor W; Davidzon, Guido A; Mormino, Elizabeth C; Poston, Kathleen L

Diagnostic performance of plasma biomarkers for detecting amyloid co‐pathology in Neuronal α‐Synuclein Disease

血浆生物标志物在检测神经元α-突触核蛋白疾病中的淀粉样蛋白共病理方面的诊断性能

Raveendran, Arya; Gupta, Ashutosh; Lewis, Leslie E; Prabhu, Krishnananda; Moorkoth, Sudheer; Smith, Alena Marie; Lorkiewicz, Sara A; Montoliu‐Gaya, Laia; Wilson, Ted N; Ashton, Nicholas; Arslan, Burak; Plastini, Melanie J; Young, Christina B; Winer, Joseph R; Shahid, Marian; Vossler, Hillary; Ramirez, Veronica; Pan, Tianyu; Kerchner, Geoffrey A; Andreasson, Katrin I; Henderson, Victor W; Montine, Thomas J; Tian, Lu; Mormino, Elizabeth C; Zetterberg, Henrik; Poston, Kathleen L; Abdelnour, Carla

Synergistic effects of APOE ε4 and Alzheimer's pathology on the neural correlates of episodic remembering in cognitively unimpaired older adults

APOE ε4 和阿尔茨海默病理对认知功能正常老年人情景记忆神经关联的协同作用

Trelle, Alexandra N; Sheng, Jintao; Wilson, Edward N; Romero, America; Park, Jennifer; Deutsch, Gayle K; Sha, Sharon J; Greicius, Michael D; Andreasson, Katrin I; Kerchner, Geoffrey A; Mormino, Elizabeth C; Wagner, Anthony D

Top-down attention and Alzheimer's pathology affect cortical selectivity during learning, influencing episodic memory in older adults

自上而下的注意力以及阿尔茨海默病病理会影响学习过程中的皮层选择性,从而影响老年人的情景记忆。

Sheng, Jintao; Trelle, Alexandra N; Romero, America; Park, Jennifer; Tran, Tammy T; Sha, Sharon J; Andreasson, Katrin I; Wilson, Edward N; Mormino, Elizabeth C; Wagner, Anthony D

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies

恢复海马葡萄糖代谢可以改善阿尔茨海默病病理状态下的认知功能

Minhas, Paras S; Jones, Jeffrey R; Latif-Hernandez, Amira; Sugiura, Yuki; Durairaj, Aarooran S; Wang, Qian; Mhatre, Siddhita D; Uenaka, Takeshi; Crapser, Joshua; Conley, Travis; Ennerfelt, Hannah; Jung, Yoo Jin; Liu, Ling; Prasad, Praveena; Jenkins, Brenita C; Ay, Yeonglong Albert; Matrongolo, Matthew; Goodman, Ryan; Newmeyer, Traci; Heard, Kelly; Kang, Austin; Wilson, Edward N; Yang, Tao; Ullian, Erik M; Serrano, Geidy E; Beach, Thomas G; Wernig, Marius; Rabinowitz, Joshua D; Suematsu, Makoto; Longo, Frank M; McReynolds, Melanie R; Gage, Fred H; Andreasson, Katrin I

Post-translational modifications linked to preclinical Alzheimer's disease-related pathological and cognitive changes

与阿尔茨海默病临床前期相关的病理和认知变化有关的翻译后修饰

Abiose, Olamide; Rutledge, Jarod; Moran-Losada, Patricia; Belloy, Michael E; Wilson, Edward N; He, Zihuai; Trelle, Alexandra N; Channappa, Divya; Romero, America; Park, Jennifer; Yutsis, Maya V; Sha, Sharon J; Andreasson, Katrin I; Poston, Kathleen L; Henderson, Victor W; Wagner, Anthony D; Wyss-Coray, Tony; Mormino, Elizabeth C