日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery

CBL0137 的化学优化,用于发现人类非洲锥虫病的先导药物

Baljinder Singh, Amrita Sharma, Naresh Gunaganti, Mitch Rivers, Pradip K Gadekar, Brady Greene, Michael Chichioco, Carlos E Sanz-Rodriguez, Courtney Fu, Catherine LeBlanc, Erin Burchfield, Nyle Sharif, Benjamin Hoffman, Gaurav Kumar, Andrei Purmal, Kojo Mensa-Wilmot, Michael P Pollastri

Physiologic Targets and Modes of Action for CBL0137, a Lead for Human African Trypanosomiasis Drug Development

非洲人类锥虫病药物研发的先导药物 CBL0137 的生理目标和作用方式

Carlos E Sanz-Rodríguez, Benjamin Hoffman, Paul J Guyett, Andrei Purmal, Baljinder Singh, Michael P Pollastri, Kojo Mensa-Wilmot

Curaxin CBL0137 has the potential to reverse HIV-1 latency

Curaxin CBL0137 有可能逆转 HIV-1 潜伏期

Maxime J Jean, Dawei Zhou, Guillaume Fiches, Weili Kong, Huachao Huang, Andrei Purmal, Katerina Gurova, Netty G Santoso, Jian Zhu

Curaxin CBL0100 Blocks HIV-1 Replication and Reactivation through Inhibition of Viral Transcriptional Elongation

Curaxin CBL0100 通过抑制病毒转录延长来阻止 HIV-1 复制和再激活

Maxime J Jean, Tsuyoshi Hayashi, Huachao Huang, Justin Brennan, Sydney Simpson, Andrei Purmal, Katerina Gurova, Michael C Keefer, James J Kobie, Netty G Santoso, Jian Zhu

Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis

发现用于治疗非洲人类锥虫病的咔唑衍生先导药物

Sarah M Thomas, Andrei Purmal, Michael Pollastri, Kojo Mensa-Wilmot

ARTIK-52 induces replication-dependent DNA damage and p53 activation exclusively in cells of prostate and breast cancer origin

ARTIK-52 仅在前列腺癌和乳腺癌细胞中诱导复制依赖性 DNA 损伤和 p53 激活

Daria Fleyshman, Peter Cheney, Anda Ströse, Shaila Mudambi, Alfiya Safina, Mairead Commane, Andrei Purmal, Kelsey Morgan, Nicholas J Wang, Joe Gray, Paul T Spellman, Natalia Issaeva, Katerina Gurova

Small-molecule xenomycins inhibit all stages of the Plasmodium life cycle

小分子异霉素可抑制疟原虫生命周期的所有阶段。

Erath, Jessey; Gallego-Delgado, Julio; Xu, Wenyue; Andriani, Grasiella; Tanghe, Scott; Gurova, Katerina V; Gudkov, Andrei; Purmal, Andrei; Rydkina, Elena; Rodriguez, Ana

Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure

鉴定粒细胞集落刺激因子和白细胞介素 6 作为 CBLB502 医疗辐射对策功效的候选生物标志物

Vadim I Krivokrysenko, Alexander N Shakhov, Vijay K Singh, Frederick Bone, Yevgeniy Kononov, Inna Shyshynova, Alec Cheney, Ratan K Maitra, Andrei Purmal, Mark H Whitnall, Andrei V Gudkov, Elena Feinstein

Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma

小分子多药耐药相关蛋白 1 抑制剂 reversan 可提高神经母细胞瘤小鼠模型的化疗治疗指数

Catherine A Burkhart, Fujiko Watt, Jayne Murray, Marina Pajic, Anatoly Prokvolit, Chengyuan Xue, Claudia Flemming, Janice Smith, Andrei Purmal, Nadezhda Isachenko, Pavel G Komarov, Katerina V Gurova, Alan C Sartorelli, Glenn M Marshall, Murray D Norris, Andrei V Gudkov, Michelle Haber