日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Covalent Ligands with AlphaFold3

利用 AlphaFold3 发现共价配体

Shamir, Yoav; Gabizon, Ronen; Rogel, Adi; Lin, David Yin-Wei; Andreotti, Amy H; London, Nir

Modulating the Binding Kinetics of Bruton's Tyrosine Kinase Inhibitors through Transition-State Effects

通过过渡态效应调节布鲁顿酪氨酸激酶抑制剂的结合动力学

Bravo, Eduardo Jr; Li, Yong; Lin, David Yin-Wei; Srinivasan, Bharath; Barone, Marco; Li, Stan Xiaogang; DelloRusso, Francesca; Rahiyanath, Anza Suneer; Corrionero, Ana; Alfonso, Patricia; Prendiville, Niall; Kozakov, Dima; Andreotti, Amy H; Tonge, Peter J

Purification and characterization of full-length monomeric TEC family kinase, ITK.

全长单体TEC家族激酶ITK的纯化和表征

Rathnayake Udumbara M, Wada Junya, Wall Vanessa E, Jones Jane, Jenkins Lisa M, Andreotti Amy H, Samelson Lawrence E

Allosteric regulation of kinase activity

激酶活性的变构调节

Andreotti, Amy H; Dötsch, Volker

Screening and Characterization of Allosteric Small Molecules Targeting Bruton's Tyrosine Kinase.

筛选和表征靶向布鲁顿酪氨酸激酶的变构小分子

Kueffer Lauren E, Lin David Yin-Wei, Amatya Neha, Serrenho Joseph, Joseph Raji E, Courtney Adam H, Andreotti Amy H

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

临床批准的BTK抑制剂对全长BTK构象的影响以及慢性淋巴细胞白血病中BTK耐药突变的发展分析

Joseph, Raji E; Wales, Thomas E; Jayne, Sandrine; Britton, Robert G; Fulton, D Bruce; Engen, John R; Dyer, Martin J S; Andreotti, Amy H

Structure of BTK kinase domain with the second-generation inhibitors acalabrutinib and tirabrutinib

BTK激酶结构域与第二代抑制剂acalabrutinib和tirabrutinib的结构

Lin, David Y; Andreotti, Amy H

Editorial: Targeting Bruton Tyrosine Kinase

社论:靶向布鲁顿酪氨酸激酶

Brunner, Cornelia; Betzler, Annika C; Brown, Jennifer R; Andreotti, Amy H; Grassilli, Emanuela

Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK

抑制BTK:域间相互作用及其在BTK调控中的重要性

Kueffer, Lauren E; Joseph, Raji E; Andreotti, Amy H

Dynamics of the Tec-family tyrosine kinase SH3 domains

Tec家族酪氨酸激酶SH3结构域的动力学

Roberts, Justin M; Tarafdar, Sreya; Joseph, Raji E; Andreotti, Amy H; Smithgall, Thomas E; Engen, John R; Wales, Thomas E