日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Biased constitutive signaling of the G protein-coupled receptor GPR35 suppresses gut barrier permeability

G蛋白偶联受体GPR35的偏向性组成型信号传导抑制肠道屏障通透性

Tezz Quon ,Li-Chiung Lin ,Amlan Ganguly ,Brian D Hudson ,Andrew B Tobin ,Graeme Milligan

Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner

游离脂肪酸受体 2 的磷酸化条形码以组织特异性方式产生

Natasja Barki, Laura Jenkins, Sara Marsango, Domonkos Dedeo, Daniele Bolognini, Louis Dwomoh, Aisha M Abdelmalik, Margaret Nilsen, Manon Stoffels, Falko Nagel, Stefan Schulz, Andrew B Tobin, Graeme Milligan

G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions

蛋白受体激酶 5/6 是 G 蛋白偶联受体 35-抑制蛋白相互作用的关键调节剂

Amlan Ganguly, Tezz Quon, Laura Jenkins, Babu Joseph, Rima Al-Awar, Andy Chevigne, Andrew B Tobin, David E Uehling, Carsten Hoffmann, Julia Drube, Graeme Milligan

Chemogenetics defines a short-chain fatty acid receptor gut-brain axis

化学遗传学定义了短链脂肪酸受体肠脑轴

Natasja Barki, Daniele Bolognini, Ulf Börjesson, Laura Jenkins, John Riddell, David I Hughes, Trond Ulven, Brian D Hudson, Elisabeth Rexen Ulven, Niek Dekker, Andrew B Tobin, Graeme Milligan

Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands

苏氨酸残基的选择性磷酸化决定了偏向配体的 GPR84-arrestin 相互作用

Sara Marsango, Richard J Ward, Laura Jenkins, Adrian J Butcher, Zobaer Al Mahmud, Louis Dwomoh, Falko Nagel, Stefan Schulz, Irina G Tikhonova, Andrew B Tobin, Graeme Milligan

Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor

激动剂诱导的孤儿受体 GPR35 直系同源物的磷酸化可作为活化传感器

Nina Divorty, Laura Jenkins, Amlan Ganguly, Adrian J Butcher, Brian D Hudson, Stefan Schulz, Andrew B Tobin, Stuart A Nicklin, Graeme Milligan

The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes

M1 毒蕈碱受体以配体调节的单体和寡聚复合物混合物的形式存在

Sara Marsango, Laura Jenkins, John D Pediani, Sophie J Bradley, Richard J Ward, Sarah Hesse, Gabriel Biener, Michael R Stoneman, Andrew B Tobin, Valerica Raicu, Graeme Milligan

M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease

M1 毒蕈碱受体激活可降低分子病理并减缓朊病毒介导的神经退行性疾病的进展

Louis Dwomoh, Mario Rossi, Miriam Scarpa, Elham Khajehali, Colin Molloy, Pawel Herzyk, Shailesh N Mistry, Andrew R Bottrill, Patrick M Sexton, Arthur Christopoulos, Jeffrey Conn, Craig W Lindsley, Sophie J Bradley, Andrew B Tobin

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival

青蒿素抗性 K13 突变重新连接恶性疟原虫的红细胞内代谢程序以提高存活率

Sachel Mok, Barbara H Stokes, Nina F Gnädig, Leila S Ross, Tomas Yeo, Chanaki Amaratunga, Erik Allman, Lev Solyakov, Andrew R Bottrill, Jaishree Tripathi, Rick M Fairhurst, Manuel Llinás, Zbynek Bozdech #, Andrew B Tobin #, David A Fidock

Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84

促炎孤儿受体 GPR84 新型拮抗剂的发现和表征

Laura Jenkins, Sara Marsango, Sarah Mancini, Zobaer Al Mahmud, Angus Morrison, Stuart P McElroy, Kirstie A Bennett, Matt Barnes, Andrew B Tobin, Irina G Tikhonova, Graeme Milligan