日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease

磷脂酶C-γ2的基因变异会改变小胶质细胞的表型和功能,并导致阿尔茨海默病风险的差异。

Andy P Tsai ,Chuanpeng Dong ,Peter Bor-Chian Lin ,Adrian L Oblak ,Gonzalo Viana Di Prisco ,Nian Wang ,Nicole Hajicek ,Adam J Carr ,Emma K Lendy ,Oliver Hahn ,Micaiah Atkins ,Aulden G Foltz ,Jheel Patel ,Guixiang Xu ,Miguel Moutinho ,John Sondek ,Qisheng Zhang ,Andrew D Mesecar ,Yunlong Liu ,Brady K Atwood ,Tony Wyss-Coray ,Kwangsik Nho ,Stephanie J Bissel ,Bruce T Lamb ,Gary E Landreth

Desorption Electrospray Ionization Mass Spectrometry Assay for Label-Free Characterization of SULT2B1b Enzyme Kinetics

采用解吸电喷雾电离质谱法进行无标记表征 SULT2B1b 酶动力学

Samadhi C Kulathunga, Nicolás M Morato, Qing Zhou, R Graham Cooks, Andrew D Mesecar

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

对一种用于治疗 COVID-19 的静脉注射冠状病毒 3CL 蛋白酶抑制剂进行临床前表征

Britton Boras # ,Rhys M Jones # ,Brandon J Anson ,Dan Arenson ,Lisa Aschenbrenner ,Malina A Bakowski ,Nathan Beutler ,Joseph Binder ,Emily Chen ,Heather Eng ,Holly Hammond ,Jennifer Hammond ,Robert E Haupt ,Robert Hoffman ,Eugene P Kadar ,Rob Kania ,Emi Kimoto ,Melanie G Kirkpatrick ,Lorraine Lanyon ,Emma K Lendy ,Jonathan R Lillis ,James Logue ,Suman A Luthra ,Chunlong Ma ,Stephen W Mason ,Marisa E McGrath ,Stephen Noell ,R Scott Obach ,Matthew N O' Brien ,Rebecca O'Connor ,Kevin Ogilvie ,Dafydd Owen ,Martin Pettersson ,Matthew R Reese ,Thomas F Rogers ,Romel Rosales ,Michelle I Rossulek ,Jean G Sathish ,Norimitsu Shirai ,Claire Steppan ,Martyn Ticehurst ,Lawrence W Updyke ,Stuart Weston ,Yuao Zhu ,Kris M White ,Adolfo García-Sastre ,Jun Wang ,Arnab K Chatterjee ,Andrew D Mesecar ,Matthew B Frieman ,Annaliesa S Anderson ,Charlotte Allerton

Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease

解耦 MERS 病毒木瓜蛋白酶样蛋白酶的去ISGylating 和去泛素化活性

Jozlyn R Clasman, Renata K Everett, Karthik Srinivasan, Andrew D Mesecar

Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus

结构引导诱变改变去泛素化活性并减弱鼠冠状病毒的发病机制

Xufang Deng, Yafang Chen, Anna M Mielech, Matthew Hackbart, Kristina R Kesely, Robert C Mettelman, Amornrat O'Brien, Mackenzie E Chapman, Andrew D Mesecar, Susan C Baker

Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNFα in Castration-Resistant Prostate Cancer

胆固醇磺基转移酶SULT2B1b调节去势抵抗性前列腺癌对死亡受体配体TNFα的敏感性

Renee E Vickman ,Jiang Yang ,Nadia A Lanman ,Gregory M Cresswell ,Faye Zheng ,Chi Zhang ,R W Doerge ,Scott A Crist ,Andrew D Mesecar ,Chang-Deng Hu ,Timothy L Ratliff

Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species

冠状病毒木瓜蛋白酶样蛋白酶与来自不同物种的干扰素刺激基因产物 15 相互作用的结构洞察

Courtney M Daczkowski, John V Dzimianski, Jozlyn R Clasman, Octavia Goodwin, Andrew D Mesecar, Scott D Pegan

X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design

MERS 冠状病毒核心木瓜蛋白酶样蛋白酶的 X 射线结构和酶活性特征及其对基于结构的药物设计的实用性

Jozlyn R Clasman, Yahira M Báez-Santos, Robert C Mettelman, Amornrat O'Brien, Susan C Baker, Andrew D Mesecar

Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus

蝙蝠 HKU4 冠状病毒 3CLpro 抑制剂的计算建模,作为开发针对新兴中东呼吸综合征 (MERS) 冠状病毒的抗病毒药物的工具

Areej Abuhammad, Rua'a A Al-Aqtash, Brandon J Anson, Andrew D Mesecar, Mutasem O Taha

Cholesterol Sulfonation Enzyme, SULT2B1b, Modulates AR and Cell Growth Properties in Prostate Cancer

胆固醇磺化酶SULT2B1b调节前列腺癌中的雄激素受体和细胞生长特性

Renee E Vickman ,Scott A Crist ,Kevin Kerian ,Livia Eberlin ,R Graham Cooks ,Grant N Burcham ,Kimberly K Buhman ,Chang-Deng Hu ,Andrew D Mesecar ,Liang Cheng ,Timothy L Ratliff