日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity

缺氧诱导中性粒细胞祖细胞中组蛋白剪切和H3K4me3丢失,导致中性粒细胞免疫功能长期受损。

Manuel A Sanchez-Garcia ,Pranvera Sadiku # ,Brian M Ortmann # ,Niek Wit # ,Yutaka Negishi # ,Patricia Coelho ,Ailiang Zhang ,Chinmayi Pednekar ,Andrew J M Howden ,David M Griffith ,Rachel Seear ,Jessica D Kindrick ,Janine Mengede ,George Cooper ,Tyler Morrison ,Emily R Watts ,Benjamin T Shimeld ,Leila Reyes ,Ananda S Mirchandani ,Simone Arienti ,Xiang Xu ,Alexander Thomson ,Alejandro J Brenes ,Helena A Turton ,Rebecca Dowey ,Rebecca C Hull ,Hazel Davidson-Smith ,Amy McLaren ,Andrew Deans ,Gourab Choudhury ,Katherine Doverman ,David Hope ,Oliver Vick ,Alastair Woodhead ,Isla Petrie ,Suzanne Green ,Nina M Rzechorzek ,Lance Turtle ,Peter J M Openshaw ,Malcolm G Semple ,J Kenneth Baillie ,Alfred A R Thompson ,David R Mole ,Alex von Kriegsheim ,Moira K B Whyte ,Musa M Mhlanga ,James A Nathan ,Sarah R Walmsley

Synaptic signatures and disease vulnerabilities of layer 5 pyramidal neurons

第五层锥体神经元的突触特征和疾病脆弱性

Gabriele Marcassa, Dan Dascenco, Blanca Lorente-Echeverría, Danie Daaboul, Jeroen Vandensteen, Elke Leysen, Lucas Baltussen, Andrew J M Howden, Joris de Wit

Inflammation and IL-4 regulate Parkinson's and Crohn's disease associated kinase LRRK2

炎症和IL-4调节帕金森病和克罗恩病相关激酶LRRK2

Dina Dikovskaya,Rebecca Pemberton,Matthew Taylor,Anna Tasegian,Purbasha Bhattacharya,Karolina Zeneviciute,Esther M Sammler,Andrew J M Howden,Dario R Alessi,Mahima Swamy

Extensive acute and sustained changes to neutrophil proteomes post-SARS-CoV-2 infection

SARS-CoV-2 感染后中性粒细胞蛋白质组发生广泛、急性和持续变化

Merete B Long, Andrew J M Howden, Holly R Keir, Christina M Rollings, Yan Hui Giam, Thomas Pembridge, Lilia Delgado, Hani Abo-Leyah, Amy F Lloyd, Gabriel Sollberger, Rebecca Hull, Amy Gilmour, Chloe Hughes, Benjamin J M New, Diane Cassidy, Amelia Shoemark, Hollian Richardson, Angus I Lamond, Doreen

Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures

定量蛋白质组学揭示组织特异性、感染诱导和物种特异性中性粒细胞蛋白质特征

Gabriel Sollberger, Alejandro J Brenes, Jordan Warner, J Simon C Arthur, Andrew J M Howden

NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease

NRF2激活可重新编程氧化代谢缺陷,恢复慢性阻塞性肺病中的巨噬细胞功能

Eilise M Ryan, Pranvera Sadiku, Patricia Coelho, Emily R Watts, Ailiang Zhang, Andrew J M Howden, Manuel A Sanchez-Garcia, Martin Bewley, Joby Cole, Brian J McHugh, Wesley Vermaelen, Bart Ghesquiere, Peter Carmeliet, Giovanny Rodriguez Blanco, Alex Von Kriegsheim, Yolanda Sanchez, William Rumsey, Ja

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration

星形胶质细胞-少突胶质细胞相互作用调节中枢神经系统再生

Irene Molina-Gonzalez ,Rebecca K Holloway ,Zoeb Jiwaji ,Owen Dando ,Sarah A Kent ,Katie Emelianova ,Amy F Lloyd ,Lindsey H Forbes ,Ayisha Mahmood ,Thomas Skripuletz ,Viktoria Gudi ,James A Febery ,Jeffrey A Johnson ,Jill H Fowler ,Tanja Kuhlmann ,Anna Williams ,Siddharthan Chandran ,Martin Stangel ,Andrew J M Howden ,Giles E Hardingham ,Veronique E Miron

An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells

B细胞成熟的整合蛋白质组和转录组定义了过渡型和成熟型B细胞的激活准备状态。

Fiamma Salerno,Andrew J M Howden,Louise S Matheson,Özge Gizlenci,Michael Screen,Holger Lingel,Monika C Brunner-Weinzierl,Martin Turner

Amino acid availability acts as a metabolic rheostat to determine the magnitude of ILC2 responses

氨基酸的可用性如同代谢调节器,决定着ILC2反应的强度。

Suzanne H Hodge ,Maria Z Krauss ,Irem Kaymak ,James I King ,Andrew J M Howden ,Gordana Panic ,Richard K Grencis ,Jonathan R Swann ,Linda V Sinclair ,Matthew R Hepworth

AMPK integrates metabolite and kinase-based immunometabolic control in macrophages

AMPK 整合巨噬细胞中的代谢物和基于激酶的免疫代谢控制

Iain R Phair, Raid B Nisr, Andrew J M Howden, Magdalena Sovakova, Noor Alqurashi, Marc Foretz, Douglas Lamont, Benoit Viollet, Graham Rena