Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms
肿瘤相关 IDH1 突变体中的活性位点重塑驱动不同的动力学特征和潜在的抗性机制
期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-024-48277-2
Matthew Mealka, Nicole A Sierra, Diego Avellaneda Matteo, Elene Albekioni, Rachel Khoury, Timothy Mai, Brittany M Conley, Nalani J Coleman, Kaitlyn A Sabo, Elizabeth A Komives, Andrey A Bobkov, Andrew L Cooksy, Steve Silletti, Jamie M Schiffer, Tom Huxford, Christal D Sohl
