日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR screen of human pancreatic cancer xenografts identifies a KLF5 proliferation vulnerability through epigenetic modifiers NCAPD2 and MTHFD1.

通过 CRISPR 筛选人类胰腺癌异种移植瘤,发现 KLF5 增殖脆弱性与表观遗传修饰因子 NCAPD2 和 MTHFD1 有关。

Maeda Masahiro, Sherman Kenna, Zhou Weiqiang, Cheng Jiaqi, Nihongaki Yuta, Idrizi Adrian, Tryggvadottir Rakel, Camacho Oscar, Shang Xingbo, Min Jimin, Koldobskiy Michael A, Maitra Anirban, Levchenko Andre, Slusher Barbara S, Ji Hongkai, Feinberg Andrew P

DNMT3A R882H Is Not Required for Disease Maintenance in Primary Human AML but Is Associated with Increased Leukemia Stem Cell Frequency

DNMT3A R882H突变并非原发性人类急性髓系白血病(AML)维持疾病状态所必需,但与白血病干细胞频率增加相关。

Thomas Köhnke #,Daiki Karigane #,Eleanor Hilgart,Amy C Fan,Kensuke Kayamori,Masashi Miyauchi,Cailin T Collins,Fabian P Suchy,Athreya Rangavajhula,Yang Feng,Yusuke Nakauchi,Eduardo Martinez-Montes,Jonas L Fowler,Kyle M Loh,Hiromitsu Nakauchi,Michael A Koldobskiy,Andrew P Feinberg,Ravindra Majeti

Biallelic variants in RNU2-2 cause a remarkably frequent developmental and epileptic encephalopathy

RNU2-2基因的双等位基因变异会导致一种非常常见的发育性和癫痫性脑病。

Jackson, Adam; Blakes, Alexander J M; Alhaddad, Bader; Henry, Olivia J; Delgado-Vega, Angelica M; Wall, Elizabeth; Abdelhadi, Ola; Agrawal, Shakti; Bakur, Khadijah; Blair, Edward; Brady, Angela F; Brittain, Helen; Chandler, Kate E; Clarke, Natasha; Danelli, Miriana; Drinkall, Nicholas; Duba, Irene; Elmslie, Frances; Ellingford, Jamie; Ewans, Lisa J; Fennell, Andrew P; Gazdagh, Gabriella; Heller, Simon P; Hammarsjö, Anna; Karrman, Kristina; Kini, Usha; Lesko, Nicole; Lindstrand, Anna; Macintosh, Rebecca; Mansour, Sahar; Menzies, Lara; Metcalfe, Kay; Milhench, Alison; Nashef, Lina; O'Keefe, Raymond T; Pacheco, Nadja Pekkola; Palmer, Elizabeth E; Parida, Amitav; Prescott, Katrina; Redman, Melody; Renieri, Alessandra; Fallerini, Chiara; Rizzo, Caterina Lo; Sachdev, Rani; Simons, Cas; Sisodiya, Sanjay M; Stewart, Helen; Stödberg, Tommy; Banos-Pinero, Benito; Taylan, Fulya; Thomas, Huw B; Tinella, Flavia; Wiafe, Samuel; Wedell, Anna; Whiffin, Nicola; Walker, Susan; Rius, Rocio; Chae, Jong Hee; Nordgren, Ann; Alkuraya, Fowzan; Lord, Jenny; Banka, Siddharth

Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration

全基因组 CRISPR 筛选发现 neddylation 是神经元衰老和阿尔茨海默病神经退行性变的一个调节因子。

Nathalie Saurat, Andrew P Minotti, Maliha T Rahman, Trisha Sikder, Chao Zhang, Daniela Cornacchia, Johannes Jungverdorben, Gabriele Ciceri, Doron Betel, Lorenz Studer

Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming

合作杂交小鼠的遗传多样性表明 FFAR3 是 ILC2 抗炎重编程的靶点

Mark Rusznak,Shinji Toki,Yajing Hao,Marc J C Todd,Liddy Malone,Julia F Goodhead,Catherine DuPuy,Weisong Zhou,Dominique Babin,Christian M Warren,Masako Abney,Matthew T Stier,Christopher M Thomas,Jing Li,Justin Jacobse,Andrew P Pahnke,Mark I Petrovic,Jacqueline-Yvonne Cephus,Shelby N Kuehnle,M Wade Calcutt,Allison E Norlander,Fang Yan,Jeremy A Goettel,Darla R Miller,Rachel M Lynch,Daniel P Cook,Dawn C Newcomb,Fei Zou,R Stokes Peebles Jr

Regulation of sodium/calcium homeostasis by BacNa(v) gene therapy rescues cardiac dysfunction in chronic heart failure

通过BacNa(v)基因疗法调节钠/钙稳态可改善慢性心力衰竭患者的心脏功能障碍

Wu, Tianyu; Li, Yongwu; Perelli, Robin M; Siu, Yiu Yan; Tornatore, Anna; Nataren, Josue; Jiang, Xixian; DeLuca, Sophia; Bers, Donald M; Henriquez, Craig; Landstrom, Andrew P; Bursac, Nenad

Comparative Effectiveness of Abatacept Versus Adalimumab in Shared Epitope Positive and Negative Patients With Rheumatoid Arthritis

阿巴西普与阿达木单抗在类风湿关节炎共享表位阳性和阴性患者中的疗效比较

Yap, Chuan Fu; Nair, Nisha; Sharma, Seema D; Bowes, John; Ariff, Amirah Binti Mohammad; Morgan, Ann W; Isaacs, John D; Wilson, Anthony G; Hyrich, Kimme L; Verstappen, Suzan; Bluett, James; Morris, Andrew P; Barton, Anne; Plant, Darren; Viatte, Sebastien

Precision medicine in type 2 diabetes: targeting SGLT2 inhibitor treatment for kidney protection

2型糖尿病精准医疗:靶向SGLT2抑制剂治疗以保护肾脏

Jansz, Thijs T; Young, Katherine G; Hopkins, Rhian; McGovern, Andrew P; Shields, Beverley M; Hattersley, Andrew T; Jones, Angus G; Pearson, Ewan R; Bingham, Coralie; Oram, Richard A; Dennis, John M

The filamentous ultrastructure of the PopZ condensate is required for its cellular function

PopZ凝聚体的丝状超微结构对其细胞功能至关重要。

Scholl, Daniel; Boyd, Tumara; Latham, Andrew P; Salazar, Alexandra; Khan, Asma M A M; Boeynaems, Steven; Holehouse, Alex S; Lander, Gabriel C; Sali, Andrej; Park, Donghyun; Deniz, Ashok A; Lasker, Keren

Initial Calcium Derangements in Major Trauma and Outcomes

严重创伤中的初始钙紊乱与预后

Schauer, Steven G; Nicholson, Susannah E; Rizzo, Julie A; Wright, Franklin L; Arana, Allyson A; April, Michael D; Barry, Lauran; Bynum, James; Cheng, Alex C; Fisher, Andrew D; Gurney, Jennifer M; Huaman, R Jimena; Jenkins, Donald H; Kirkwood, Brian J; Lambert, Bethany C; Long, Brit J; Mancha, Fabiola; Martinez, Melody A; Meledeo, Michael A; Mendez, Jessica; Newton, Isabel; Shackelford, Stacy A; Sifuentes, Dayana; Bebarta, Vikhyat S; Cap, Andrew P