日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A high-throughput screen to identify novel synthetic lethal compounds for the treatment of E-cadherin-deficient cells

通过高通量筛选鉴定用于治疗 E-钙粘蛋白缺陷细胞的新型合成致死化合物

Henry Beetham, Augustine Chen, Bryony J Telford, Andrew Single, Kate E Jarman, Kurt Lackovic, Andreas Luxenburger, Parry Guilford

Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells

变构 AKT 抑制剂靶向 E-钙粘蛋白缺乏细胞中的合成致死弱点

Nicola Bougen-Zhukov, Yasmin Nouri, Tanis Godwin, Megan Taylor, Christopher Hakkaart, Andrew Single, Tom Brew, Elizabeth Permina, Augustine Chen, Michael A Black, Parry Guilford