文献库，生知库 | 链接生命科学的每一步

日期影响因子

Aging impairs the antiviral defense in Caenorhabditis elegans due to loss of DRH-1/RIG-I deSUMOylation by ULP-4/SENP7

衰老会削弱秀丽隐杆线虫的抗病毒防御能力，这是由于ULP-4/SENP7介导的DRH-1/RIG-I去SUMO化作用丧失所致。

期刊:EMBO Reports

影响因子:6.5

doi:10.1038/s44319-025-00589-0.

Yun Zhang ,Andrew V Samuelson

发表日期：2025

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Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

同源域相互作用蛋白激酶在秀丽隐杆线虫正常衰老过程中维持神经元稳态，并通过血清素能和GABA能神经元系统性地调节寿命。

影响因子:6.4

doi:10.7554/eLife.85792

Maria I Lazaro-Pena ,Adam B Cornwell ,Carlos A Diaz-Balzac ,Ritika Das ,Zachary C Ward ,Nicholas Macoretta ,Juilee Thakar ,Andrew V Samuelson

发表日期：2023

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Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase

自溶酶体生物合成和发育性衰老均受Spns1和v-ATPase的调控。

期刊:Autophagy

影响因子:14.6

doi:10.1080/15548627.2016.1256934

Tomoyuki Sasaki ,Shanshan Lian ,Alam Khan ,Jesse R Llop ,Andrew V Samuelson ,Wenbiao Chen ,Daniel J Klionsky ,Shuji Kishi

发育与干细胞

发表日期：2017

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The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans

同源域相互作用蛋白激酶 HPK-1 通过控制 HSF-1 分子伴侣网络和 TORC1 限制性自噬来维持秀丽隐杆线虫的蛋白质稳态和寿命

期刊:PLoS Genetics

doi:10.1371/journal.pgen.1007038

Ritika Das, Justine A Melo, Manjunatha Thondamal, Elizabeth A Morton, Adam B Cornwell, Beresford Crick, Joung Heon Kim, Elliot W Swartz, Todd Lamitina, Peter M Douglas, Andrew V Samuelson

细胞生物学

发表日期：2017

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