Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity.
致癌代谢物 2-羟基戊二酸抑制 DNA 聚合酶 β 的基础蛋白水平，从而增强烷化剂和 PARG 抑制剂诱导的细胞毒性
期刊:DNA Repair
影响因子:2.7
doi:10.1016/j.dnarep.2024.103700
Saville Kate M, Al-Rahahleh Rasha Q, Siddiqui Aisha H, Andrews Morgan E, Roos Wynand P, Koczor Christopher A, Andrews Joel F, Hayat Faisal, Migaud Marie E, Sobol Robert W
