日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy

对人类短尾蛋白DNA识别的结构性见解以及用于癌症治疗的新型结合剂的发现

Newman, Joseph A; Gavard, Angeline E; Imprachim, Nergis; Aitkenhead, Hazel; Sheppard, Hadley E; Te Poele, Robert; Clarke, Paul A; Hossain, Mohammad Anwar; Temme, Louisa; Oh, Hans J; Wells, Carrow I; Davis-Gilbert, Zachary W; Workman, Paul; Gileadi, Opher; Drewry, David H

Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies.

线粒体 ROS 信号传导需要不间断的电子流,而果蝇衰老过程中这种信号传导会丧失

Graham Charlotte, Stefanatos Rhoda, Yek Angeline E H, Spriggs Ruth V, Loh Samantha H Y, Uribe Alejandro Huerta, Zhang Tong, Martins L Miguel, Maddocks Oliver D K, Scialo Filippo, Sanz Alberto

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

对 Artemis 核酸内切酶的结构和机制的深入研究及其抑制策略

Yosaatmadja, Yuliana; Baddock, Hannah T; Newman, Joseph A; Bielinski, Marcin; Gavard, Angeline E; Mukhopadhyay, Shubhashish M M; Dannerfjord, Adam A; Schofield, Christopher J; McHugh, Peter J; Gileadi, Opher

Epitope-directed monoclonal antibody production using a mixed antigen cocktail facilitates antibody characterization and validation

使用混合抗原混合物进行表位导向单克隆抗体生产有利于抗体的表征和验证

Oi Wah Liew #, Samantha S M Ling #, Shera Lilyanna, Yue Zhou, Peipei Wang, Jenny P C Chong, Yan Xia Ng, Angeline E S Lim, Eliot R Y Leong, Qifeng Lin, Teck Kwang Lim, Qingsong Lin, Enoch M W Ng, Tuck Wah Ng, A Mark Richards

Author Correction: Epitope-directed monoclonal antibody production using a mixed antigen cocktail facilitates antibody characterization and validation

作者更正:使用混合抗原混合物进行表位导向的单克隆抗体生产有助于抗体的表征和验证。

Liew, Oi Wah; Ling, Samantha S M; Lilyanna, Shera; Zhou, Yue; Wang, Peipei; Chong, Jenny P C; Ng, Yan Xia; Lim, Angeline E S; Leong, Eliot R Y; Lin, Qifeng; Lim, Teck Kwang; Lin, Qingsong; Ng, Enoch M W; Ng, Tuck Wah; Richards, A Mark

Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

沃纳解旋酶的解旋酶核心结构,微卫星不稳定性癌症的关键靶点

Joseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer, Patrick Werni, Leonhard Geist, Jark Böttcher, John R Engen, Klaus Rumpel, Matthias Samwer, Mark Petronczki, Opher Gileadi

A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin

一个能结合与泛素结构不同的结构折叠的泛素结合域

Michael Lim ,Joseph A Newman ,Hannah L Williams ,Laura Masino ,Hazel Aitkenhead ,Angeline E Gravard ,Opher Gileadi ,Jesper Q Svejstrup

Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae

在甲型流感病毒和肺炎链球菌共感染期间,TLR2-MYD88-NLRP3 信号轴介导 IL-1β 产生增强

Angeline E Rodriguez, Christopher Bogart, Christopher M Gilbert, Jonathan A McCullers, Amber M Smith, Thirumala-Devi Kanneganti, Christopher R Lupfer