Hit-to-Lead Optimization of Acetazolamide-Based Bacterial Carbonic Anhydrase Inhibitors with Efficacy In Vivo for Treatment of Vancomycin-Resistant Enterococci Septicemia
基于乙酰唑胺的细菌碳酸酐酶抑制剂的先导化合物优化,以评估其在体内治疗耐万古霉素肠球菌败血症的疗效。
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01584
Holly, Katrina J; Tharra, Prabhakara R; Abutaleb, Nader S; Nocentini, Alessio; Abouelkhair, Ahmed A; Youse, Molly S; Marapaka, Anil Kumar; S Abdelsattar, Abdallah; An, Weiwei; Drummond, Faith L; Snell, Olivia C; Supuran, Claudiu T; Seleem, Mohamed N; Flaherty, Daniel P