Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
通过共同靶向 MEK 和 IGF-1R/PI3K 可以克服黑色素瘤中由 RAF 激酶开关介导的对 BRAF 抑制剂的获得性耐药性
期刊:Cancer Cell
影响因子:48.8
doi:10.1016/j.ccr.2010.11.023
Jessie Villanueva, Adina Vultur, John T Lee, Rajasekharan Somasundaram, Mizuho Fukunaga-Kalabis, Angela K Cipolla, Bradley Wubbenhorst, Xiaowei Xu, Phyllis A Gimotty, Damien Kee, Ademi E Santiago-Walker, Richard Letrero, Kurt D'Andrea, Anitha Pushparajan, James E Hayden, Kimberly Dahlman Brown, Sylv
