日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo

手性很重要:小干扰 RNA 末端的立体定义的硫代磷酸酯键可改善体内药理学

Hartmut Jahns, Nate Taneja, Jennifer L S Willoughby, Masaaki Akabane-Nakata, Christopher R Brown, Tuyen Nguyen, Anna Bisbe, Shigeo Matsuda, Matt Hettinger, Rajar M Manoharan, Kallanthottathil G Rajeev, Martin A Maier, Ivan Zlatev, Klaus Charisse, Martin Egli, Muthiah Manoharan

Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing

小环状干扰 RNA(sciRNA)作为基因沉默的有效治疗平台

Hartmut Jahns, Rohan Degaonkar, Peter Podbevsek, Swati Gupta, Anna Bisbe, Krishna Aluri, John Szeto, Pawan Kumar, Sarah LeBlanc, Tim Racie, Christopher R Brown, Adam Castoreno, Dale C Guenther, Vasant Jadhav, Martin A Maier, Janez Plavec, Martin Egli, Muthiah Manoharan, Ivan Zlatev

Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity

4'-和2'-修饰对siRNA核酸酶抗性、热稳定性和RNAi活性协同作用的结构基础

Joel M Harp, Dale C Guenther, Anna Bisbe, Lydia Perkins, Shigeo Matsuda, Gopal R Bommineni, Ivan Zlatev, Donald J Foster, Nate Taneja, Klaus Charisse, Martin A Maier, Kallanthottathil G Rajeev, Muthiah Manoharan, Martin Egli