日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer

胰腺癌对致癌 KRAS 抑制剂的耐药机制

Julien Dilly #, Megan T Hoffman #, Laleh Abbassi #, Ziyue Li #, Francesca Paradiso #, Brendan D Parent, Connor J Hennessey, Alexander C Jordan, Micaela Morgado, Shatavisha Dasgupta, Giselle A Uribe, Annan Yang, Kevin S Kapner, Felix P Hambitzer, Li Qiang, Hanrong Feng, Jacob Geisberg, Junning Wang, 

Development and Characterization of Selective FAK Inhibitors and PROTACs with In Vivo Activity

具有体内活性的选择性 FAK 抑制剂和 PROTAC 的开发和表征

Eriko Koide, Mikaela L Mohardt, Zainab M Doctor, Annan Yang, Mingfeng Hao, Katherine A Donovan, Christina C Kuismi, Alissa J Nelson, Kathryn Abell, Mike Aguiar, Jianwei Che, Matthew P Stokes, Tinghu Zhang, Andrew J Aguirre, Eric S Fischer, Nathanael S Gray, Baishan Jiang, Behnam Nabet

Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer

协调的转录和分解代谢程序支持胰腺癌中铁依赖性RAS-MAPK通路抑制的适应

Mirunalini Ravichandran ,Jingjie Hu ,Charles Cai ,Nathan P Ward ,Anthony Venida ,Callum Foakes ,Miljan Kuljanin ,Annan Yang ,Connor J Hennessey ,Yang Yang ,Brandon R Desousa ,Gilles Rademaker ,Annelot A L Staes ,Zeynep Cakir ,Isha H Jain ,Andrew J Aguirre ,Joseph D Mancias ,Yin Shen ,Gina M DeNicola ,Rushika M Perera

NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins

NCOA4 介导的铁蛋白吞噬作用是一种胰腺癌依赖性,通过维持铁硫簇蛋白的铁生物利用度实现

Naiara Santana-Codina, Maria Quiles Del Rey #, Kevin S Kapner #, Huan Zhang #, Ajami Gikandi, Callum Malcolm, Clara Poupault, Miljan Kuljanin, Kristen M John, Douglas E Biancur, Brandon Chen, Nupur K Das, Kristen E Lowder, Connor J Hennessey, Wesley Huang, Annan Yang, Yatrik M Shah, Jonathan A Nowak

cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes

cIAP1/2 拮抗剂通过 T 细胞依赖性单核吞噬细胞重编程消除 MHC I 类阴性肿瘤

Kevin Roehle, Li Qiang, Katherine S Ventre, Daniel Heid, Lestat R Ali, Patrick Lenehan, Max Heckler, Stephanie J Crowley, Courtney T Stump, Gabrielle Ro, Anže Godicelj, Aladdin M Bhuiyan, Annan Yang, Maria Quiles Del Rey, Tamara Biary, Adrienne M Luoma, Patrick T Bruck, Jana F Tegethoff, Svenja L No

Molecular basis for substrate recruitment to the PRMT5 methylosome

PRMT5 甲基化酶体底物募集的分子基础

Kathleen M Mulvaney, Christa Blomquist, Nischal Acharya, Ruitong Li, Matthew J Ranaghan, Meghan O'Keefe, Diego J Rodriguez, Michael J Young, Devishi Kesar, Debjani Pal, Matthew Stokes, Alissa J Nelson, Sidharth S Jain, Annan Yang, Zachary Mullin-Bernstein, Josie Columbus, Fazli K Bozal, Adam Skepner

Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo

Sulfopin 是一种 Pin1 共价抑制剂,可在体内阻断 Myc 驱动的肿瘤。

Christian Dubiella # ,Benika J Pinch # ,Kazuhiro Koikawa ,Daniel Zaidman ,Evon Poon ,Theresa D Manz ,Behnam Nabet ,Shuning He ,Efrat Resnick ,Adi Rogel ,Ellen M Langer ,Colin J Daniel ,Hyuk-Soo Seo ,Ying Chen ,Guillaume Adelmant ,Shabnam Sharifzadeh ,Scott B Ficarro ,Yann Jamin ,Barbara Martins da Costa ,Mark W Zimmerman ,Xiaolan Lian ,Shin Kibe ,Shingo Kozono ,Zainab M Doctor ,Christopher M Browne ,Annan Yang ,Liat Stoler-Barak ,Richa B Shah ,Nicholas E Vangos ,Ezekiel A Geffken ,Roni Oren ,Eriko Koide ,Samuel Sidi ,Ziv Shulman ,Chu Wang ,Jarrod A Marto ,Sirano Dhe-Paganon ,Thomas Look ,Xiao Zhen Zhou ,Kun Ping Lu ,Rosalie C Sears ,Louis Chesler ,Nathanael S Gray ,Nir London

SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization

SMAD4抑制FOSL1表达和胰腺癌转移定植

Chao Dai,Jonathan P Rennhack,Taylor E Arnoff,Maneesha Thaker,Scott T Younger,John G Doench,August Yue Huang,Annan Yang,Andrew J Aguirre,Belinda Wang,Evan Mun,Joyce T O'Connell,Ying Huang,Katherine Labella,Jessica A Talamas,Ji Li,Nina Ilic,Justin Hwang,Andrew L Hong,Andrew O Giacomelli,Ole Gjoerup,David E Root,William C Hahn

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

ESCRT 旁系同源酶 VPS4A 和 VPS4B 在 18q 或 16q 染色体缺失的癌症中发生合成致死相互作用

Jasper E Neggers, Brenton R Paolella, Adhana Asfaw, Michael V Rothberg, Thomas A Skipper, Annan Yang, Radha L Kalekar, John M Krill-Burger, Neekesh V Dharia, Guillaume Kugener, Jérémie Kalfon, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y Li, Liam F Spurr, Westley W Wu, Adam D D

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

CDK7抑制增强基因组不稳定性,从而触发小细胞肺癌中的抗肿瘤免疫反应

Hua Zhang ,Camilla L Christensen ,Ruben Dries ,Matthew G Oser ,Jiehui Deng ,Brian Diskin ,Fei Li ,Yuanwang Pan ,Xuzhu Zhang ,Yandong Yin ,Eleni Papadopoulos ,Val Pyon ,Cassandra Thakurdin ,Nicholas Kwiatkowski ,Kandarp Jani ,Alexandra R Rabin ,Dayanne M Castro ,Ting Chen ,Heather Silver ,Qingyuan Huang ,Mirna Bulatovic ,Catríona M Dowling ,Belen Sundberg ,Alan Leggett ,Michela Ranieri ,Han Han ,Shuai Li ,Annan Yang ,Kristen E Labbe ,Christina Almonte ,Vladislav O Sviderskiy ,Max Quinn ,Jack Donaghue ,Eric S Wang ,Tinghu Zhang ,Zhixiang He ,Vamsidhar Velcheti ,Peter S Hammerman ,Gordon J Freeman ,Richard Bonneau ,William G Kaelin Jr ,Kate D Sutherland ,Ariena Kersbergen ,Andrew J Aguirre ,Guo-Cheng Yuan ,Eli Rothenberg ,George Miller ,Nathanael S Gray ,Kwok-Kin Wong