日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

MNK抑制通过降低eIF4E磷酸化和c-MYC表达,增强KRAS突变型结直肠癌对mTORC1抑制剂的敏感性。

John R P Knight ,Constantinos Alexandrou ,George L Skalka ,Nikola Vlahov ,Kathryn Pennel ,Leah Officer ,Ana Teodosio ,Georgios Kanellos ,David M Gay ,Sebastian May-Wilson ,Ewan M Smith ,Arafath K Najumudeen ,Kathryn Gilroy ,Rachel A Ridgway ,Dustin J Flanagan ,Rachael C L Smith ,Laura McDonald ,Craig MacKay ,Anne Cheasty ,Kerri McArthur ,Emma Stanway ,Joshua D Leach ,Rene Jackstadt ,Joseph A Waldron ,Andrew D Campbell ,Georgios Vlachogiannis ,Nicola Valeri ,Kevin M Haigis ,Nahum Sonenberg ,Christopher G Proud ,Neil P Jones ,Martin E Swarbrick ,Heather J McKinnon ,William J Faller ,John Le Quesne ,Joanne Edwards ,Anne E Willis ,Martin Bushell ,Owen J Sansom

Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins

针对溴结构域和植物同源结构域指状 (BRPF) 蛋白家族的化学探针的设计

Niall Igoe, Elliott D Bayle, Cynthia Tallant, Oleg Fedorov, Julia C Meier, Pavel Savitsky, Catherine Rogers, Yannick Morias, Sarah Scholze, Helen Boyd, Danen Cunoosamy, David M Andrews, Anne Cheasty, Paul E Brennan, Susanne Müller, Stefan Knapp, Paul V Fish

Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties

氨基噻唑作为具有细胞抗侵袭特性的 LIMK 抑制剂的发现、开发和 SAR

Mark D Charles, Joanna L Brookfield, Tennyson C Ekwuru, Martin Stockley, John Dunn, Michelle Riddick, Tim Hammonds, Elisabeth Trivier, Gavin Greenland, Ai Ching Wong, Anne Cheasty, Susan Boyd, Diane Crighton, Michael F Olson