Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)
PPARα 功能丧失会促进脂质稳态的表观遗传失调,导致代谢功能障碍相关脂肪肝 (MASLD) 中的铁死亡和焦亡脂毒性
期刊:Frontiers in Molecular Medicine
影响因子:
doi:10.3389/fmmed.2023.1283170
Claudia Theys, Tineke Vanderhaeghen, Evelien Van Dijck, Cedric Peleman, Anne Scheepers, Joe Ibrahim, Ligia Mateiu, Steven Timmermans, Tom Vanden Berghe, Sven M Francque, Wim Van Hul, Claude Libert, Wim Vanden Berghe