CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids
CEA 表达的异质性和可塑性导致患者来源的结肠直肠癌类器官对 CEA 靶向双特异性免疫治疗抗体 cibisatamab (CEA-TCB) 产生耐药性
期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.3
doi:10.1186/s40425-019-0575-3
Reyes Gonzalez-Exposito, Maria Semiannikova, Beatrice Griffiths, Khurum Khan, Louise J Barber, Andrew Woolston, Georgia Spain, Katharina von Loga, Ben Challoner, Radhika Patel, Michael Ranes, Amanda Swain, Janet Thomas, Annette Bryant, Claire Saffery, Nicos Fotiadis, Sebastian Guettler, David Mansfi
