日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model

大鼠模型和确认细胞模型中万古霉素与哌拉西林/他唑巴坦之间缺乏协同肾毒性

Gwendolyn M Pais, Jiajun Liu, Sean N Avedissian, Danielle Hiner, Theodoros Xanthos, Athanasios Chalkias, Ernesto d'Aloja, Emanuela Locci, Annette Gilchrist, Walter C Prozialeck, Nathaniel J Rhodes, Thomas P Lodise, Julie C Fitzgerald, Kevin J Downes, Athena F Zuppa, Marc H Scheetz

Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β

溶血磷脂酸通过 LPA2 和 Gαq 介导的 Rho 和 αvβ6 整合素依赖性 TGF-β 激活,增加近端小管细胞分泌促纤维化细胞因子 PDGF-B 和 CTGF

Hui Geng, Rongpei Lan, Prajjal K Singha, Annette Gilchrist, Paul H Weinreb, Shelia M Violette, Joel M Weinberg, Pothana Saikumar, Manjeri A Venkatachalam

Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways

凝血酶通过 PAR1 与 Galphaq 的偶联以及 ERK1/2 与 Rho 激酶信号通路的协同作用诱导成纤维细胞 CCL2/JE 的产生和释放

Xiaoling Deng, Paul F Mercer, Chris J Scotton, Annette Gilchrist, Rachel C Chambers