日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An immunohistochemical atlas of necroptotic pathway expression

坏死性凋亡通路表达的免疫组织化学图谱

Shene Chiou # ,Aysha H Al-Ani # ,Yi Pan ,Komal M Patel ,Isabella Y Kong ,Lachlan W Whitehead ,Amanda Light ,Samuel N Young ,Marilou Barrios ,Callum Sargeant ,Pradeep Rajasekhar ,Leah Zhu ,Anne Hempel ,Ann Lin ,James A Rickard ,Cathrine Hall ,Pradnya Gangatirkar ,Raymond Kh Yip ,Wayne Cawthorne ,Annette V Jacobsen ,Christopher R Horne ,Katherine R Martin ,Lisa J Ioannidis ,Diana S Hansen ,Jessica Day ,Ian P Wicks ,Charity Law ,Matthew E Ritchie ,Rory Bowden ,Joanne M Hildebrand ,Lorraine A O'Reilly ,John Silke ,Lisa Giulino-Roth ,Ellen Tsui ,Kelly L Rogers ,Edwin D Hawkins ,Britt Christensen ,James M Murphy ,André L Samson

Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation

抑制剂确定了 mTOR 信号在 MLKL 激活下游坏死性凋亡执行中的辅助作用

Sarah E Garnish, Christopher R Horne, Yanxiang Meng, Samuel N Young, Annette V Jacobsen, Joanne M Hildebrand, James M Murphy

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

人类常见的 MLKL 多态性可抵抗磷酸化的负向调控

Sarah E Garnish, Katherine R Martin, Maria Kauppi, Victoria E Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C Tovey Crutchfield, Komal M Patel, Annette V Jacobsen, Georgia K Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R Horne, Cathrine Hall, S

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

VEGFR/PDGFR 酪氨酸激酶抑制剂 ABT-869 通过靶向 RIPK1 激酶来阻断坏死性凋亡

Catia L Pierotti, Annette V Jacobsen, Christoph Grohmann, Ruby K Dempsey, Nima Etemadi, Joanne M Hildebrand, Cheree Fitzgibbon, Samuel N Young, Katherine A Davies, Wilhelmus J A Kersten, John Silke, Kym N Lowes, Hélène Jousset Sabroux, David C S Huang, Mark F van Delft, James M Murphy, Guillaume Les

An Exploratory Study: Undergraduates' Perspectives on how Threshold Concepts Influence Professional Identity

一项探索性研究:本科生对阈限概念如何影响职业认同的看法

O'Mahony, Shenae E; Joosten, Annette V; O'Brien, Jennifer

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

开发 NanoLuc 靶向蛋白质降解剂和通用报告系统,以对标标签靶向降解平台

Christoph Grohmann #, Charlene M Magtoto #, Joel R Walker, Ngee Kiat Chua, Anna Gabrielyan, Mary Hall, Simon A Cobbold, Stephen Mieruszynski, Martin Brzozowski, Daniel S Simpson, Hao Dong, Bridget Dorizzi, Annette V Jacobsen, Emma Morrish, Natasha Silke, James M Murphy, Joan K Heath, Andrea Testa, C

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL

膜通透性由小鼠和人类坏死性凋亡效应物 MLKL 的直系同源物中的不同表位介导

Ashish Sethi #, Christopher R Horne #, Cheree Fitzgibbon, Karyn Wilde, Katherine A Davies, Sarah E Garnish, Annette V Jacobsen, André L Samson, Joanne M Hildebrand, Ahmad Wardak, Peter E Czabotar, Emma J Petrie, Paul R Gooley, James M Murphy

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL

Lck 抑制剂 AMG-47a 可阻断坏死性凋亡,并提示 RIPK1 参与了 MLKL 下游的信号传导

Annette V Jacobsen, Catia L Pierotti, Kym N Lowes, Amanda E Au, Ying Zhang, Nima Etemadi, Cheree Fitzgibbon, Wilhelmus J A Kersten, André L Samson, Mark F van Delft, David C S Huang, Hélène Jousset Sabroux, Guillaume Lessene, John Silke, James M Murphy

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

MLKL 的构象相互转化和与 RIPK3 的脱离先于细胞坏死性凋亡而死亡

Sarah E Garnish #, Yanxiang Meng #, Akiko Koide #, Jarrod J Sandow, Eric Denbaum, Annette V Jacobsen, Wayland Yeung, Andre L Samson, Christopher R Horne, Cheree Fitzgibbon, Samuel N Young, Phoebe P C Smith, Andrew I Webb, Emma J Petrie, Joanne M Hildebrand, Natarajan Kannan, Peter E Czabotar, Shohei

A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells

用于对小鼠和人类细胞中的 RIPK1、RIPK3 和 MLKL 进行成像的工具箱

André L Samson, Cheree Fitzgibbon, Komal M Patel, Joanne M Hildebrand, Lachlan W Whitehead, Joel S Rimes, Annette V Jacobsen, Christopher R Horne, Xavier J Gavin, Samuel N Young, Kelly L Rogers, Edwin D Hawkins, James M Murphy