日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic.

吗啡烷衍生的双重μ-κ阿片受体激动剂镇痛药的合成与药理学研究

Varga Balazs R, Uprety Rajendra, Paul Barnali, Knoll Alexis, Ramos-Gonzalez Nokomis, Appourchaux Kevin, Taylor Tori, Turgutalp Bengisu, Shinouchi Ryosuke, Eans Shainnel O, Williams Ashai K, Vasquez-Grinnell Steven G, Zaidi Saheem, Nazarova Antonina L, Varadi Andras, Le Rouzic Valerie, Brown Taylor G, Martinez Shani, Ansonoff Michael, Dardashti Rebecca Notis, Hunkele Amanda, Subrath Joan, Welch Matthew, Xu Jin, Rossi Grace C, Pintar John, Pasternak Gavril W, Katritch Vsevolod, McLaughlin Jay P, Pan Ying Xian, Majumdar Susruta

Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models

Oxa-Iboga 生物碱在动物模型中不具有心脏风险,并能干扰阿片类药物的使用

Václav Havel #, Andrew C Kruegel #, Benjamin Bechand #, Scot McIntosh, Leia Stallings, Alana Hodges, Madalee G Wulf, Mel Nelson, Amanda Hunkele, Michael Ansonoff, John E Pintar, Christopher Hwu, Rohini S Ople, Najah Abi-Gerges, Saheem A Zaidi, Vsevolod Katritch, Mu Yang, Jonathan A Javitch, Susruta

Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy

帽柱木碱的位点选择性CH官能化揭示了一种调节阿片受体信号传导效力的分子开关

Bhowmik, Srijita; Galeta, Juraj; Havel, Václav; Nelson, Melissa; Faouzi, Abdelfattah; Bechand, Benjamin; Ansonoff, Mike; Fiala, Tomas; Hunkele, Amanda; Kruegel, Andrew C; Pintar, John E; Majumdar, Susruta; Javitch, Jonathan A; Sames, Dalibor

Oxidative Metabolism as a Modulator of Kratom's Biological Actions

氧化代谢作为 Kratom 生物作用的调节剂

Soumen Chakraborty, Rajendra Uprety, Samuel T Slocum, Takeshi Irie, Valerie Le Rouzic, Xiaohai Li, Lisa L Wilson, Brittany Scouller, Amy F Alder, Andrew C Kruegel, Michael Ansonoff, Andras Varadi, Shainnel O Eans, Amanda Hunkele, Abdullah Allaoa, Sanjay Kalra, Jin Xu, Ying Xian Pan, John Pintar, Bro

Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template

基于卡芬太尼模板的新型μ-δ阿片受体异聚体选择性激动剂的合成及药理学研究

Abdelfattah Faouzi, Rajendra Uprety, Ivone Gomes, Nicolas Massaly, Attila I Keresztes, Valerie Le Rouzic, Achla Gupta, Tiffany Zhang, Hye Jean Yoon, Michael Ansonoff, Abdullah Allaoa, Ying Xian Pan, John Pintar, Jose A Morón, John M Streicher, Lakshmi A Devi, Susruta Majumdar

7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects

7-羟基帽柱木碱是帽柱木碱的活性代谢产物,也是其镇痛作用的关键介质。

Kruegel, Andrew C; Uprety, Rajendra; Grinnell, Steven G; Langreck, Cory; Pekarskaya, Elizabeth A; Le Rouzic, Valerie; Ansonoff, Michael; Gassaway, Madalee M; Pintar, John E; Pasternak, Gavril W; Javitch, Jonathan A; Majumdar, Susruta; Sames, Dalibor

The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor

抗抑郁药噻奈普汀的行为效应需要 Mu-阿片受体

Benjamin Adam Samuels, Katherine M Nautiyal, Andrew C Kruegel, Marjorie R Levinstein, Valerie M Magalong, Madalee M Gassaway, Steven G Grinnell, Jaena Han, Michael A Ansonoff, John E Pintar, Jonathan A Javitch, Dalibor Sames, René Hen

Opioids and opioid receptors orchestrate wound repair

阿片类物质和阿片受体协调伤口修复

Wang, Ying; Gupta, Mihir; Poonawala, Tasneem; Farooqui, Mariya; Li, Yunfang; Peng, Fei; Rao, Sheldon; Ansonoff, Michael; Pintar, John E; Gupta, Kalpna

Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors

预测LY2940094(一种伤害感受素受体拮抗剂)疗效和副作用的临床前研究结果

Witkin, Jeffrey M; Rorick-Kehn, Linda M; Benvenga, Mark J; Adams, Benjamin L; Gleason, Scott D; Knitowski, Karen M; Li, Xia; Chaney, Steven; Falcone, Julie F; Smith, Janice W; Foss, Julie; Lloyd, Kirsti; Catlow, John T; McKinzie, David L; Svensson, Kjell A; Barth, Vanessa N; Toledo, Miguel A; Diaz, Nuria; Lafuente, Celia; Jiménez, Alma; Benito, Alfonso; Pedregal, Conception; Martínez-Grau, Maria A; Post, Anke; Ansonoff, Michael A; Pintar, John E; Statnick, Michael A

Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants

丁丙诺啡镇痛作用是通过传统和截短的μ阿片受体剪接变体的组合介导的

Grinnell, Steven G; Ansonoff, Michael; Marrone, Gina F; Lu, Zhigang; Narayan, Ankita; Xu, Jin; Rossi, Grace; Majumdar, Susruta; Pan, Ying-Xian; Bassoni, Daniel L; Pintar, John; Pasternak, Gavril W