日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

SARS-CoV-2 3CLpro 中的 L50F、E166A 和 L167F 替换在体外被蛋白酶抑制剂选择并赋予对尼玛瑞韦的抗性

Dirk Jochmans, Cheng Liu, Kim Donckers, Antitsa Stoycheva, Sandro Boland, Sarah K Stevens, Chloe De Vita, Bert Vanmechelen, Piet Maes, Bettina Trüeb, Nadine Ebert, Volker Thiel, Steven De Jonghe, Laura Vangeel, Dorothée Bardiot, Andreas Jekle, Lawrence M Blatt, Leonid Beigelman, Julian A Symons, Pie

Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

在小鼠疗效模型中,STING 激动剂 ALG-031048 瘤内和皮下给药后肿瘤消退

Andreas Jekle, Santosh Kumar Thatikonda, Ruchika Jaisinghani, Suping Ren, April Kinkade, Sarah K Stevens, Antitsa Stoycheva, Vivek K Rajwanshi, Caroline Williams, Jerome Deval, Sucheta Mukherjee, Qingling Zhang, Sushmita Chanda, David B Smith, Lawrence M Blatt, Julian A Symons, Francois Gonzalvez, L

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model

ALG-097111 是一种强效且选择性的 SARS-CoV-2 3-胰凝乳蛋白酶样半胱氨酸蛋白酶抑制剂,在叙利亚仓鼠模型中显示出体内疗效。

Vandyck, Koen; Abdelnabi, Rana; Gupta, Kusum; Jochmans, Dirk; Jekle, Andreas; Deval, Jerome; Misner, Dinah; Bardiot, Dorothée; Foo, Caroline S; Liu, Cheng; Ren, Suping; Beigelman, Leonid; Blatt, Lawrence M; Boland, Sandro; Vangeel, Laura; Dejonghe, Steven; Chaltin, Patrick; Marchand, Arnaud; Serebryany, Vladimir; Stoycheva, Antitsa; Chanda, Sushmita; Symons, Julian A; Raboisson, Pierre; Neyts, Johan

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

甲状腺激素受体β激动剂对基因转录的调控在治疗非酒精性脂肪性肝炎(NASH)的临床开发中

Xuan G Luong, Sarah K Stevens, Andreas Jekle, Tse-I Lin, Kusum Gupta, Dinah Misner, Sushmita Chanda, Sucheta Mukherjee, Caroline Williams, Antitsa Stoycheva, Lawrence M Blatt, Leonid N Beigelman, Julian A Symons, Pierre Raboisson, David McGowan, Koen Vandyck, Jerome Deval

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

2'-氟-4'-氯甲基胞苷三磷酸选择性抑制呼吸道合胞病毒RNA聚合酶的分子机制

Deval, Jerome; Hong, Jin; Wang, Guangyi; Taylor, Josh; Smith, Lucas K; Fung, Amy; Stevens, Sarah K; Liu, Hong; Jin, Zhinan; Dyatkina, Natalia; Prhavc, Marija; Stoycheva, Antitsa D; Serebryany, Vladimir; Liu, Jyanwei; Smith, David B; Tam, Yuen; Zhang, Qingling; Moore, Martin L; Fearns, Rachel; Chanda, Sushmita M; Blatt, Lawrence M; Symons, Julian A; Beigelman, Leo